Evidence map›Paper›PMID 40284486›Full record

ArticlePharmaceutics2025

Novel Artificial 5'UTR Increase Modified mRNA Translation When Injected into Mouse Heart.

Ann Anu Kurian, Matteo Ghiringhelli, Eyal Shalom, Gayatri Mainkar, Magdalena M Żak, Matthew Adjmi, Jeffrey Downey, Seonghun Yoon, Nicole Dubois, Filip K Swirski and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ann Anu KurianCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Matteo GhiringhelliCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-2191-6942
Eyal ShalomCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Gayatri MainkarCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Magdalena M ŻakCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-8625-7274
Matthew AdjmiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jeffrey DowneyCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Seonghun YoonCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0009-0009-5498-4053
Nicole DuboisCell, Development/Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Filip K SwirskiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lior ZangiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Funding

Mechanisms of de novo cardiac sarcomere assemblyR01HL173318 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Nicole Dubois · 2024 to 2026
$2.0M
NHLBI NIH HHS R01 HL173318
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

5′ untranslated regioncardiac gene therapymodified RNA (modRNA)synthetic RNA motiftranslation efficiency

Identifiers

PMID40284486
PMCPMC12030343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.