Evidence map›Paper›PMID 40284454›Full record

ArticlePharmaceutics2025

Predictive Lung- and Spleen-Targeted mRNA Delivery with Biodegradable Ionizable Lipids in Four-Component LNPs.

Juan Heredero, Álvaro Peña, Esther Broset, Beatriz Blandín, Diego de Miguel, Teresa Alejo, Alfonso Toro, Elena Mata, Alexandre López-Gavín, Ana Gallego-Lleyda and 10 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Juan HerederoCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0009-0005-5523-5522
Álvaro PeñaCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-3517-4102
Esther BrosetCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0003-4155-749X
Beatriz BlandínCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Diego de MiguelCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-8486-8514
Teresa AlejoCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-9324-0446
Alfonso ToroCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-0087-7780
Elena MataCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-4086-7544
Alexandre López-GavínCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Ana Gallego-LleydaCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Diego CasabonaCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Verónica LampayaCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Ana LarragaCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Esther Pérez-HerránCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0000-0002-4464-9528
David LunaCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.ORCID 0009-0000-3448-1314
Irene OreraProteomics Research Core Facility, Aragon Health Sciences Institute (IACS), 50009 Zaragoza, Spain.ORCID 0000-0002-7508-4750
Eduardo RomanosMedical Imaging and Phenotyping Core Facility, Aragon Health Sciences Institute (IACS), 50009 Zaragoza, Spain.ORCID 0000-0002-9918-3374
Alba GarcíaMedical Imaging and Phenotyping Core Facility, Aragon Health Sciences Institute (IACS), 50009 Zaragoza, Spain.
Juan Martínez-OlivánCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.
Javier Giménez-WarrenCertest Pharma, Certest Biotec S.L., San Mateo de Gállego, 50840 Zaragoza, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

extrahepatic deliveryfour-component LNPsionizable lipidslipid nanoparticleslung targetingmRNAprotein coronaspleen targeting

Identifiers

PMID40284454
PMCPMC12030499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.