Evidence map›Paper›PMID 40284407›Full record

ArticlePharmaceutics2025

Translational Pharmacokinetic-Pharmacodynamic Modeling of a Novel Oral Dihydroorotate Dehydrogenase (DHODH) Inhibitor, HOSU-53 (JBZ-001).

Joo Young Na, Min Hai, Kyeongmin Kim, Sandip M Vibhute, Chad E Bennett, Christopher C Coss, Mitch A Phelps

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joo Young NaDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
Min HaiDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-8675-8976
Kyeongmin KimDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-8333-8001
Sandip M VibhuteDrug Discovery Shared Resource, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-2186-1366
Chad E BennettDrug Discovery Shared Resource, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0009-3514-3195
Christopher C CossDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-8184-9190
Mitch A PhelpsDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-1615-5280

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Harry T. Mangurian Foundation N/ANCI NIH HHS P30CA016058Paula and Rodger Riney Foundation N/APelotonia N/AWhiteOak Group Predoctoral fellowship
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DHODH inhibitorfirst-in-humanHOSU-53JBZ-001PBPK modelingPK/PD modeling

Identifiers

PMID40284407
PMCPMC12030426

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.