Evidence map›Paper›PMID 40284366›Full record

ArticlePolymers2025

NIR pH-Responsive PEGylated PLGA Nanoparticles as Effective Phototoxic Agents in Resistant PDAC Cells.

Degnet Melese Dereje, Francesca Bianco, Carlotta Pontremoli, Alessandra Fiorio Pla, Nadia Barbero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Degnet Melese DerejeNIS Interdepartmental and INSTM Reference Centre, Department of Chemistry, University of Torino, Via G. Quarello 15A, 10135 Torino, Italy.
Francesca BiancoDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Turin, Italy.
Carlotta PontremoliNIS Interdepartmental and INSTM Reference Centre, Department of Chemistry, University of Torino, Via G. Quarello 15A, 10135 Torino, Italy.
Alessandra Fiorio PlaDepartment of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123 Turin, Italy.ORCID 0000-0003-4576-1594
Nadia BarberoNIS Interdepartmental and INSTM Reference Centre, Department of Chemistry, University of Torino, Via G. Quarello 15A, 10135 Torino, Italy.ORCID 0000-0001-6421-3492

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide due to its resistance to conventional therapies that is attributed to its dense and acidic tumor microenvironment. Chemotherapy based on gemcitabine usually lacks efficacy due to poor drug penetration and the metabolic characteristics of the cells adapted to grow at a more acidic pH

Indexed as

heptamethine-cyanine dyesPEGylated PLGA nanoparticlesphotodynamic therapyresistant PDAC cells

Identifiers

PMID40284366
PMCPMC12030558

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.