Evidence map›Paper›PMID 40284303›Full record

ArticlePolymers2025

Effect of Polydopamine-Coated Strontium-Doped Hydroxyapatite Nanowires on Bone Marrow Mesenchymal Stem Cells and Umbilical Vein Endothelial Cells.

Hanjing Li, Yucheng Liu, Longhai Peng, Chunyuan Du, Kui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanjing LiSchool of Advanced Manufacturing, Nanchang University, Nanchang 330031, China.
Yucheng LiuSchool of Advanced Manufacturing, Nanchang University, Nanchang 330031, China.
Longhai PengSchool of Advanced Manufacturing, Nanchang University, Nanchang 330031, China.
Chunyuan DuKey Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Kui ZhouSchool of Advanced Manufacturing, Nanchang University, Nanchang 330031, China.ORCID 0000-0003-1103-2166

Funding

China Postdoctoral Science Foundation 2024M762378Jiangxi Provincial Natural Science Foundation 20232BAB215016, 20224ACB214005, 20242BAB25358, 20232BBE50017National Natural Science Foundation of China 32001017State Key Laboratory of Materials Processing and Die & Mold Technology of Huazhong University of Science and Technology P2023-017Young Elite Scientists Sponsorship Program by JXAST 2024QT13
6 · The paper itself

Abstract

Hydroxyapatite nanowires (HAW) can effectively improve the bone repair ability in bone engineered tissue. However, due to their single function, the application of HAWs in biological tissue engineering materials is limited. In this study, strontium-doped hydroxyapatite nanowires (SrHAW) were synthesized by a hydrothermal method and coated with polydopamine (PDA) to improve the function of HAWs. The material structure, biocompatibility evaluation, and differentiation capability testing of PDA-coated strontium-doped hydroxyapatite (SrHAW@PDA) nanowires were conducted. Then, the nanowires were co-cultured with rat bone marrow mesenchymal stem cells (BMSCs) and rat umbilical vein endothelial cells (UVECs) to prepare cell spheroids. Compared with the undoped and uncoated HAW, the SrHAW@PDA nanowires enhanced the cell activity and their angiogenesis and osteogenesis abilities. In addition, their performance in the three-dimensional spheroid also played a positive role in the cells in the spheroid. Due to the presence of PDA, the adhesion between the cells in the three-dimensional spheroid and the nanowires were enhanced. In summary, these results show that SrHAW@PDA has the potential to be used as an alternative material to regulate cell biological activity in three-dimensional cell spheroids.

Indexed as

cell spheroidhydroxyapatite nanowirespolydopaminestrontium

Identifiers

PMID40284303
PMCPMC12030473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.