ArticlePolymers2025
Design, Characterization, and Release Kinetics of a Hybrid Hydrogel Drug Delivery System for Sustained Hormone Therapy.
Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- QbD aided optimization and molecular docking of pH-sensitive hydrogels for targeted colon delivery in ulcerative colitis.RSC advances · 2026Article
- Development of Oral pH-Sensitive Eudragit L100-FunctionalizedACS omega · 2026Article
- Light-Triggered and Sustained Delivery of Dexamethasone Using Chitosan-Coated PLGA Nanoparticles for Posterior Eye Disease Treatment.ACS omega · 2026Article
- Curcumin-based smart responsive hydrogels: A controlled release system for bone defect regeneration.Regenerative therapy · 2026Review
- Freeze-Thaw-Induced Physically Cross-Linked Poly(Vinyl Alcohol)/Alginate Hydrogels Incorporating Silver-Doped Zinc Oxide and Clove Oil.Biopolymers · 2026Article
- Lactic Acid-Loaded Hydrogels for Post-Episiotomy Wound Healing: Microenvironment Engineering and Regenerative Strategies-A Narrative Review.Molecules (Basel, Switzerland) · 2026Review
- Hydrogels-Advanced Polymer Platforms for Drug Delivery.Polymers · 2026Review
- Mechanomedicine in digestive surgery: a theranostic framework integrating mechanical diagnostics and therapeutic modulation across the perioperative continuum.Theranostics · 2026Review
- Bio-Polymers Based Functionalized Hydrogel Carriers for Targeted Oncology Therapies: Current Progress and Future Perspectives.International journal of nanomedicine · 2026Review
- Dual-Drug Delivery Systems Using Hydrogel-Nanoparticle Composites: Recent Advances and Key Applications.Gels (Basel, Switzerland) · 2025Review
- Dynamic Boronate Ester Based Hydrogel with Enhanced Mechanical Properties and Multi-Stimuli-Triggered Release for Tissue Repair and Antioxidant Therapy.Gels (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study presents a hybrid hydrogel system designed for the targeted delivery of letrozole, a key therapeutic agent in breast cancer treatment. Letrozole-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles were embedded within a poly(2-hydroxyethyl methacrylate) (pHEMA) matrix coated onto acrylamide-grafted low-density polyethylene (AAm-g-LDPE), yielding a mechanically stable system with tunable drug release. Field emission scanning electron microscopy (FE-SEM) and confocal microscopy confirmed uniform microparticle distribution. In vitro release studies in simulated uterine fluid (SUF) at 37 °C demonstrated a sustained release profile over 32 days, with a reduced initial burst effect (~15% lower than conventional PLGA systems). The system's release kinetics followed the Higuchi model (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.