Evidence map›Paper›PMID 40284180›Full record

ArticleNutrients2025

A Combination of 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone and Curcumin Synergistically Reduces Neuroinflammation in Cortical Microglia by Targeting the NLRP3 Inflammasome and the NOX2/Nrf2 Signaling Pathway.

Emma Marcolin, Chiara Chemello, Anna Piovan, Massimo Barbierato, Paolo Morazzoni, Eugenio Ragazzi, Morena Zusso

Abstract read
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma MarcolinDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.ORCID 0009-0004-1856-2447
Chiara ChemelloDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.
Anna PiovanDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.
Massimo BarbieratoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.
Paolo MorazzoniNutraceutical Division, Distillerie Umberto Bonollo S.p.A., 35035 Mestrino, Italy.
Eugenio RagazziDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.ORCID 0000-0002-0390-6823
Morena ZussoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.ORCID 0000-0002-6577-2947

Funding

Distillerie Bonollo Umberto S.p.A. ricerca commissionataUniversity of Padua ex 60%
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CurcuminInflammasomesLactonesMicrogliaNADPH Oxidase 2Neuroinflammatory DiseasesNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinAnimalsAnti-Inflammatory AgentsCells, CulturedCell SurvivalCerebral CortexDrug SynergismNitric OxideRatsAnti-Inflammatory AgentsCurcuminCybb protein, ratgamma-valerolactoneInflammasomesLactonesNADPH Oxidase 2Nfe2l2 protein, ratNF-E2-Related Factor 2Nitric OxideNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, rat5-(3′,4′-dihydroxyphenyl)-γ-valerolactonecurcuminneuroinflammationNLRP3 inflammasomeNrf2 signalingsynergistic effect

Identifiers

PMID40284180
PMCPMC12030566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.