ArticleNutrients2025
Vitamin D and Cognitive Impairment.
Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dose-response effects of vitamin D supplementation on vitamin D status, glycosylated hemoglobin and total cholesterol in patients with diabetes mellitus: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Vitamin D and L-Cysteine as Potential Regulators of Adiponectin in Alzheimer's Disease: A Narrative Review.Nutrients · 2026Review
- Vitamin D and Brain Health.Advances in experimental medicine and biology · 2026Review
- The incremental predictive value of biological aging indicators for cognitive impairment in older adults: a longitudinal analysis on the Mr. OS & Ms. OS cohort.Alzheimer's research & therapy · 2025Article
- Neuroprotective synergy of vitamin D and exercise: a narrative review of preclinical and clinical evidence on aging-related neuroplasticity and cognitive health.Frontiers in nutrition · 2025Review
- Interpretable machine learning models for predicting cognitive impairment using NHANES neuropsychological tests: nutritional and sociodemographic associations.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundVitamin D deficiency is recognized as a significant public health concern, and it has been identified as one of the potentially modifiable risk factors for mild cognitive impairment (MCI). However, evidence regarding the relationship between vitamin D status and cognitive function remains conflicting.
objectiveTherefore, this study aimed to examine the prevalence of vitamin D deficiency in the Thai elderly population and an association between vitamin D status and cognitive function, adiposity, and insulin sensitivity.
methodsThis study enrolled participants aged 55-80 years with normal cognitive function (normal group) or MCI from the prospective cohort in the "Holistic approach of Alzheimer's disease in Thai people (HADThai study)". We used the baseline clinical data to determine the prevalence of vitamin D deficiency and its association between vitamin D status and cognitive function, adiposity, and insulin sensitivity.
resultsA total of 718 subjects (71.9% women) with a mean age of 65.7 ± 5.8 years and a mean BMI of 23.9 ± 3.7 kg/m
conclusionsOur study emphasized the high prevalence of vitamin D inadequacy among elderly individuals and an inverse association of vitamin D status and adiposity and insulin resistance. These findings emphasize the importance of addressing vitamin D deficiency in the elderly population to improve overall health outcomes. Nevertheless, our results do not support a direct role of vitamin D status in cognitive decline in this population. Further research, particularly studies with longer follow-up periods and the inclusion of patients with dementia with details of vitamin D supplementation, is needed to clarify the potential role of vitamin D in cognitive decline and neurodegenerative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.