ArticleNutrients2025
The Impact of Protein Feed on the Urea-to-Creatinine Ratio-A Retrospective Single-Center Study.
Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Curcumin/Turmeric Supplementation on Kidney Function in Individuals With Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Endocrinology, diabetes & metabolism · 2026Pooled it
- A comparative study of baked and traditional fermented milk: physicochemical characteristics and biological effects in wistar albino rats.Scientific reports · 2026Article
- Association of Urea-to-Creatinine Ratio with Functional Outcomes in Patients with Traumatic Brain Injury.Journal of clinical medicine · 2026Article
- Dietary Melegueta pepper alleviates heat stress-induced disruptions in haematobiochemical parameters, liver histopathology and growth performance indices of broiler chickens in tropical conditions.Tropical animal health and production · 2026Article
- Association between urea-to-creatinine ratio trajectories and clinical outcomes in chronic critical illness patients: a retrospective cohort study.Frontiers in nutrition · 2026Article
- The Urea-Creatinine Ratio as Marker of Catabolism Is Affected by Continuous Renal Replacement Therapy.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe urea-to-creatinine ratio (UCR) serves as a biochemical marker for catabolism in the intensive care unit (ICU). UCR increases mainly due to an elevated urea generation from increased protein metabolism. This study aimed to evaluate the impact of protein intake on UCR progression in ICU patients.
methodsThe inclusion criteria of this retrospective, single-center analysis required an ICU stay of at least 14 days without requirement of renal replacement therapy (n = 346 patients). Patients were grouped based on daily mean protein intake per kilogram between days 5 and 14: low (≤0.8 g/kg/d, n = 120), medium (0.9-1.2 g/kg/d, n = 132), and high (≥1.3 g/kg/d, n = 94). Data on daily protein and calorie intake, calorie deficit, urea generation rate, serum creatinine, urea, UCR and creatinine clearances were analysed. Risk factors for developing a high UCR were determined via logistic regression analysis adjusted for sex, age, bodyweight, disease severity (SAPS III admission score) as well as mean protein intake and calorie deficit during day 5 and 14 on ICU.
resultsHigher protein intake was associated with increased calorie intake, lower calorie deficit, and led to an elevated urea generation rate and higher UCR. Renal function and serum urea trends were comparable between all groups, while creatinine was significantly lower in the high-protein group. Risk factors for developing an elevated UCR included older age, female sex and higher protein intake.
conclusionsAn elevated UCR in the early ICU phase may indicate an increased protein metabolism, not only deriving from catabolism but also from a high protein feed.
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