ReviewInternational journal of environmental research and public health2025
The Global Burden of Periodontal Disease: A Narrative Review on Unveiling Socioeconomic and Health Challenges.
Review in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Interleukin-23 Receptor and Interleukin-17 Receptor A: Splice Variants, Isoforms and Their Relationship With Periodontitis-A Systematic Review and Bioinformatic Analysis.Journal of cellular and molecular medicine · 2026Pooled it
- Resveratrol as an Adjunct Therapy in Periodontal Disease: A Systematic Review and Meta-Analysis.Nutrients · 2026Pooled it
- The association of periodontitis with telomere length: a meta-analysis.BMC medical genomics · 2026Pooled it
- Is Obesity a Risk Factor for Periodontitis? A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Effectiveness of vitamin C and D supplementation as an adjunct in the management of gingivitis in school-going children: a randomized controlled trial.BMC public health · 2026Trial
- Oral Health in Somalia: Unmasking a Neglected Dimension of Public Health.Public health challenges · 2026Article
- Periodontal Disease and Edentulism Trends in Older Women of China and Association of Southeast Asian Nations, 1990 to 2033.International dental journal · 2026Article
- Demystifying Nanotherapeutic Modalities: Unravelling the Mysteries from Antibiofilm Mechanisms to Regenerative and Clinical Translation.Biomedicines · 2026Review
- Synergistic Effects of Social Determinants of Health and Periodontitis on Premature Cardiovascular Mortality: A Nationally Representative Cohort Study.Journal of public health dentistry · 2026Article
- Azithromycin in Dentistry: From Systemic Antibiotic to a Candidate for Local Therapeutic Delivery.Pharmaceutics · 2026Review
- Article
- Salivary protein macromolecules as diagnostic and therapeutic biomarkers linking oral health and neurodegenerative diseases-emerging mechanisms and future perspectives.Inflammopharmacology · 2026Review
- Bridging Guidelines and Oral Healthcare: Development and Initial Validation of a Questionnaire Assessing Early-Career Dentists' Attitudes Toward Periodontal Therapy-A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Association between smoking and periodontitis severity in patients attending a periodontology clinic: a cross-sectional study.BMC oral health · 2026Article
- GLP-1 Receptor Agonists in Periodontology: Mechanisms, Clinical Evidence, and Implications for Care.Biomolecules · 2026Review
- Improvement of Alveolar Bone in a Child with Severe Congenital Neutropenia: Long-Term Clinical Outcomes.Dentistry journal · 2026Article
- Oral Hygiene Behaviors, Periodontal Awareness, and Self-Reported Periodontal Symptoms Among Adults: A Cross-Sectional Survey Study.Healthcare (Basel, Switzerland) · 2026Article
- Heterogeneous Systemic IgG Responses to Porphyromonas gingivalis Gingipains in Advanced Periodontitis.Clinical and experimental dental research · 2026Article
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Canine Periodontal Disease in an Urban Clinical Setting and Its Relationship with Host Factors and the Subgingival Bacterial Profile in Ecuador.Animals : an open access journal from MDPI · 2026Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Periodontal disease is a prevalent chronic inflammatory condition that impacts over a billion people worldwide, leading to substantial tooth loss, reduced quality of life, and heightened systemic health risks. This narrative review synthesizes current evidence regarding the global burden of periodontal disease, its established associations with systemic conditions including cardiovascular disease, diabetes, adverse pregnancy outcomes, respiratory infections, and neurodegenerative disorders, and its significant socioeconomic implications. The review focused on the following research question: What is the global burden of periodontal disease, and how do its systemic and socioeconomic implications necessitate integrated public health strategies? A structured search of the PubMed, Scopus, and WHO databases from 2000 to 2024 was conducted to identify relevant literature using key terms, including "periodontal disease", "global burden", "systemic inflammation", and "public health strategies". Out of 312 initially identified articles, 175 satisfied the inclusion criteria for the final synthesis. The findings underscore the significance of periodontal disease as a modifiable risk factor for various noncommunicable diseases, the influence of healthcare disparities on disease progression, and the critical necessity for integrated public health strategies to mitigate the global burden of periodontal disease and its consequences. The review concludes that coordinated policy reform, health system integration, and enhanced research efforts are crucial for mitigating the global burden of periodontal disease and advancing health equity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.