Evidence map›Paper›PMID 40283771›Full record

ReviewInternational journal of environmental research and public health2025

Rapid-Acting Treatments for Perinatal Depression: Clinical Landscapes and Future Horizons.

Emily M Beydler, Amanda Koire, Elizabeth Steuber, Joseph J Taylor, Reid J Mergler

Abstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emily M BeydlerDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-6703-9132
Amanda KoireAMC Department of Psychiatry, Mass General Brigham, Boston, MA 02115, USA.ORCID 0000-0002-8320-1910
Elizabeth SteuberHarvard Medical School, Boston, MA 02115, USA.
Joseph J TaylorAMC Department of Psychiatry, Mass General Brigham, Boston, MA 02115, USA.ORCID 0000-0002-9185-0427
Reid J MerglerDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7209-649X

Funding

Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Deriving TMS Targets for Mood Valence and Mood Stabilization in Bipolar DisorderK23MH129829 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI Joseph Jeffrey Taylor · 2022 to 2026
$978k
NIMH NIH HHS K23 MH129829NIMH NIH HHS R01 MH113929
6 · The paper itself

Abstract

Perinatal depression affects approximately 1 in 5 women and is the leading cause of maternal mortality in the United States. In addition to evidence-based treatment with antidepressant medications, there has been a push to identify rapid-acting options for pregnant and postpartum individuals. This paper reviews the evidence behind new pharmacological agents (neurosteroids and ketamine) and non-pharmacological approaches (transcranial magnetic stimulation). The paper also highlights the risks and benefits of electroconvulsive therapy and selective serotonin reuptake inhibitors. Based on recent studies and research, the paper provides considerations when prescribing these modalities including: timing of symptom onset, severity of presentation, breastfeeding priorities, prior treatment response and treatment availability and cost.

Indexed as

Antidepressive AgentsDepressionDepression, PostpartumPregnancy ComplicationsElectroconvulsive TherapyFemaleHumansPregnancySelective Serotonin Reuptake InhibitorsTranscranial Magnetic StimulationAntidepressive AgentsSelective Serotonin Reuptake Inhibitorsantidepressantsneurosteroidsperinatal depressiontranscranial magnetic stimulation

Identifiers

PMID40283771
PMCPMC12027204

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.