ArticleInternational journal of environmental research and public health2025
Positive Childhood Experiences, Cognition, and Biomarkers of Alzheimer's Disease.
Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Beyond Adversity: Definitions, Retrospective Assessment, and Experimental Manipulation of Positive Early-Life Experiences.Brain sciences · 2026Review
- From Early Adversity to Neurodegeneration: Stress Biomarkers as Predictive Signals for Lifespan Brain Health.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Positive childhood experiences (PCEs) have unknown effects on late life cognition and Alzheimer's Disease biomarkers. We examined 406 Asian, 1179 Black, 349 Latinx, and 498 White KHANDLE and STAR study participants with data on PCEs, longitudinal cognitive measures, MRI (n = 560), and amyloid PET (n = 281). We conducted mediation and multigroup models within the structural equation modeling framework allowing us to examine the direct association of PCEs with episodic memory level and change as well as the indirect effects of PCEs through education. We additionally conducted linear regressions examining the association of PCEs with MRI and amyloid PET outcomes. Average participant age was 74 (53-90) and 62% were female. Overall, PCEs were positively associated with memory intercept and change. Education significantly mediated the association between PCEs and memory intercept. PCEs were not associated with hippocampal volume or amyloid burden in the combined sample or across individual ethnocultural groups. PCEs are positively related to episodic memory through the promotion of educational attainment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.