Evidence map›Paper›PMID 40283738›Full record

ArticleInternational journal of environmental research and public health2025

HLA Polymorphisms Linked to the Severity and Extent of Periodontitis in Patients with Type 1 Diabetes from a Brazilian Mixed Population.

Carlos Felipe Sousa Menezes, Lucas Meneses Lage, Luís Gustavo Souza Santos, Gilvan Cortês Nascimento, Marcelo Magalhães, Alexandre Facundo, Dayse Aparecida Silva, Luís Cristóvão Porto, Marília Brito Gomes, Manuel Dos Santos Faria and 2 more

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In one paragraph

Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carlos Felipe Sousa MenezesSchool of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil.ORCID 0000-0002-5938-1691
Lucas Meneses LageSchool of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil.
Luís Gustavo Souza SantosSchool of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil.
Gilvan Cortês NascimentoResearch Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil.
Marcelo MagalhãesResearch Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil.ORCID 0000-0002-0464-4343
Alexandre FacundoResearch Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil.ORCID 0000-0002-1465-860X
Dayse Aparecida SilvaDNA Diagnostic Laboratory, Rio de Janeiro State University, Rio de Janeiro 20550-900, RJ, Brazil.ORCID 0000-0003-3805-2837
Luís Cristóvão PortoDNA Diagnostic Laboratory, Rio de Janeiro State University, Rio de Janeiro 20550-900, RJ, Brazil.ORCID 0000-0003-1499-1821
Marília Brito GomesDiabetes Unit, State University of Rio de Janeiro, Rio de Janeiro 20551-030, RJ, Brazil.
Manuel Dos Santos FariaResearch Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil.
Rossana Sousa AzulayResearch Group in Clinical Endocrinology and Molecular Metabolism, São Luís 65020-070, MA, Brazil.ORCID 0000-0002-6097-8145
Vandilson RodriguesSchool of Dentistry, Federal University of Maranhão, São Luís 65085-580, MA, Brazil.ORCID 0000-0002-6785-7864

Funding

CAPES Finance code 001
6 · The paper itself

Abstract

This study aimed to investigate the relationship between Class II human leukocyte antigen (HLA) alleles (DRB1, DQA1, and DQB1) and the severity and extent of periodontitis in patients with Type 1 diabetes (T1D). A cross-sectional study was conducted with 49 patients with T1D. Demographic data and diabetes history were collected. A clinical examination was performed to assess periodontal variables. The patients were categorized by the periodontitis severity and the extent of periodontitis. Peripheral blood samples were analyzed to identify the percentage of autosomal ancestry (Native American, European, and African) and the HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles. The DRB1*03 and DRB1*15 haplogroups were significantly associated with an increased risk of generalized periodontitis (OR = 19.8, 95% CI = 1.14-346,

Indexed as

Diabetes Mellitus, Type 1PeriodontitisPolymorphism, GeneticAdolescentAdultAllelesBrazilCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseHaplotypesHLA-DQ alpha-ChainsHLA-DQ beta-ChainsHLA-DRB1 ChainsHumansMaleHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DRB1 Chainshuman leukocyte antigenperiodontal diseasestype 1 diabetes

Identifiers

PMID40283738
PMCPMC12026859

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.