ReviewMicromachines2025
Seeking Solutions for Inclusively Economic, Rapid, and Safe Molecular Detection of Respiratory Infectious Diseases: Comprehensive Review from Polymerase Chain Reaction Techniques to Amplification-Free Biosensing.
Review in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frequent outbreaks of respiratory infectious diseases, driven by diverse pathogens, have long posed significant threats to public health, economic productivity, and societal stability. Respiratory infectious diseases are highly contagious, characterized by short incubation periods, diverse symptoms, multiple transmission routes, susceptibility to mutations, and distinct seasonality, contributing to their propensity for outbreaks. The absence of effective antiviral treatments and the heightened vulnerability of individuals with weakened immune systems make them more susceptible to infection, with severe cases potentially leading to complications or death. This situation becomes particularly concerning during peak seasons, such as influenza outbreaks. Therefore, early detection, diagnosis, and treatment are critical, alongside the prevention of cross-infection, ensuring patient safety, and controlling healthcare costs. To address these challenges, this review aims to identify a comprehensive, rapid, safe, and cost-effective diagnostic approach for respiratory infectious diseases. This approach is framed within the existing hierarchical healthcare system, focusing on establishing diagnostic capabilities at hospitals, community, and home levels to effectively tackle the above issues. In addition to PCR and isothermal amplification, the review also explores emerging molecular diagnostic strategies that may better address the evolving needs of respiratory disease diagnostics. A key focus is the transition from amplification technologies to amplification-free biosensing approaches, with particular attention given to their potential for home-based testing. This shift seeks to overcome the limitations of conventional amplification methods, particularly in decentralized and home diagnostics, offering a promising solution to enhance diagnostic speed and safety during outbreaks. In the future, with the integration of AI technologies into molecular amplification technologies, biosensors, and various application levels, the inclusively economic, rapid, and safe respiratory disease diagnosis solutions will be further optimized, and their accessibility will become more widespread.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.