Evidence map›Paper›PMID 40283228›Full record

ReviewLife (Basel, Switzerland)2025

Exploring the Relationship Between Obstructive Sleep Apnea and Olfactory Function.

Antonino Maniaci, Mario Lentini, Maria Rita Bianco, Daniele Salvatore Paternò, Salvatore Lavalle, Annalisa Pace, Giannicola Iannella, Paolo Boscolo-Rizzo, Miguel Mayo-Yanez, Christian Calvo-Henriquez and 2 more

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonino ManiaciDepartment of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.ORCID 0000-0002-1251-0185
Mario LentiniDepartment of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.ORCID 0009-0004-8127-5045
Maria Rita BiancoOtolaryngology Unit, Department of Health Science, University Magna Graecia of Catanzaro, Viale Europa, Germaneto, 88100 Catanzaro, Italy.ORCID 0000-0003-4512-1378
Daniele Salvatore PaternòASP Ragusa, 97100 Ragusa, Italy.ORCID 0009-0003-0215-5620
Salvatore LavalleDepartment of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.ORCID 0009-0009-5556-6259
Annalisa PaceDepartment of 'Organi di Senso', University "Sapienza", 00185 Rome, Italy.
Giannicola IannellaStudy Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), 75019 Paris, France.ORCID 0000-0003-1781-2809
Paolo Boscolo-RizzoSection of Otolaryngology, Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0002-4635-7959
Miguel Mayo-YanezStudy Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), 75019 Paris, France.ORCID 0000-0002-1829-6597
Christian Calvo-HenriquezStudy Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), 75019 Paris, France.ORCID 0000-0003-3580-0967
Jerome R LechienStudy Group of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), 75019 Paris, France.ORCID 0000-0002-0845-0845
Luigi La ViaDepartment of Anesthesia and Intensive Care 1, University Hospital Policlinico "G. Rodolico-San Marco", 95123 Catania, Italy.ORCID 0000-0002-2156-7554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is increasingly recognized as a chronic condition that is closely interrelated to olfactory disorders, with a significant contribution to quality of health and overall quality of life. This narrative review aims to provide a thorough overview of the emerging evidence that now integrates these two previously considered distinct physiologic systems. Studies published recently have reported a significantly higher frequency of olfactory dysfunction among OSA patients compared to the general population, which raises the possibility of a causal relationship. We explore the postulated mechanisms behind this association, namely, the chronic intermittent hypoxia, local inflammatory effect, and neuroanatomical changes attributed to OSA. The review further explores the clinical impacts of this relationship through proposing the potential for an olfactory assessment to be used as a diagnostic modality for OSA and the effects of OSA treatment on olfactory function. Thus, we explore the difficulties in treating patients who experience both and suggest future areas for research. This review attempts to bridge the gap between the existing literature and impending investigation necessary for a better management of the interaction of sleep apnea and the human sense of smell.

Indexed as

chronic intermittent hypoxiacontinuous positive airway pressureInflammationmultidisciplinary managementneurocognitive functionobstructive sleep apneaolfactory assessmentolfactory dysfunctionolfactory trainingsleep fragmentation

Identifiers

PMID40283228
PMCPMC12028956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.