ArticleLife (Basel, Switzerland)2025
3D Spheroid Cultures for Salivary Gland Tissue Engineering: Effects of Fibroblast on Epithelial Cell Function.
Lan Thi Phuong Nguyen, Joo Hyun Kim, Jiwon Son, Sung Sik Hur, Minyong Lee, Hyung Kwon Byeon, Jin-Young Kim, Myung Jin Ban, Joo Hyun Kim, Man Ryul Lee and 2 more
Abstract read
In one paragraphArticle in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
12 authors.
Lan Thi Phuong NguyenSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.ORCID 0009-0007-3784-074X Joo Hyun KimSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.
Jiwon SonSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.
Sung Sik HurSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.
Minyong LeeSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.
Hyung Kwon ByeonDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University Seoul Hospital, Seoul 04401, Republic of Korea.ORCID 0000-0003-3709-2028 Jin-Young KimDivision of Respiratory Allergy and Critical Care Medicine, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.
Myung Jin BanDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.ORCID 0000-0003-2069-2422 Joo Hyun KimDepartment of Otorhinolaryngology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea.ORCID 0000-0002-8533-9649 Man Ryul LeeDepartment of Stem Cell and Regenerative Biotechnology, Konkuk Institute of Science and Technology, Konkuk University, Seoul 05029, Republic of Korea.
Jae Hong ParkDepartment of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Republic of Korea.
Yongsung HwangSoonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Republic of Korea.ORCID 0000-0001-5558-5171 Funding
National Research Foundation of Korea 2019R1A5A8083404National Research Foundation of Korea 2021R1C1C1008363National Research Foundation of Korea RS-2023-00284258Soonchunhyang University Not available
6 · The paper itselfAbstract
Three-dimensional (3D) spheroid cultures are crucial for modeling salivary gland (SG) morphogenesis and advancing regenerative medicine. This study evaluated the effects of varying ratios of mouse SG-derived epithelial cells co-cultured with human dermal fibroblasts (hDFs), identifying a 2:1 ratio (spheroids containing 67% EpCAM
Indexed as
3D spheroidsepithelial cellsfibroblastssalivary glandssenescence
Identifiers
PMID40283162
PMCPMC12028948
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