Evidence map›Paper›PMID 40283130›Full record

ReviewLife (Basel, Switzerland)2025

Antioxidant and Anti-Inflammatory Defenses in Huntington's Disease: Roles of NRF2 and PGC-1α, and Therapeutic Strategies.

Francesco D'Egidio, Elvira Qosja, Fabrizio Ammannito, Skender Topi, Michele d'Angelo, Annamaria Cimini, Vanessa Castelli

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco D'EgidioDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0001-9695-6274
Elvira QosjaDepartment of Clinical Disciplines, University 'Alexander Xhuvani' of Elbasan, 3001 Elbasan, Albania.
Fabrizio AmmannitoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0009-0005-5416-4187
Skender TopiDepartment of Clinical Disciplines, University 'Alexander Xhuvani' of Elbasan, 3001 Elbasan, Albania.ORCID 0000-0002-6661-8116
Michele d'AngeloDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3693-840X
Annamaria CiminiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-2737-7970
Vanessa CastelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-7005-3218

Funding

Dompé (Italy) B19J23000180005Ministero dell'università e della ricerca E19J21012890001Ministero dell'università e della ricerca ECS00000041
6 · The paper itself

Abstract

Huntington's disease (HD) is a detrimental neurodegenerative disease caused by the expansion of a CAG triplet in the

Indexed as

antioxidant therapyHuntington’s diseaseneurodegenerationneuroinflammationNRF2oxidative stressPGC-1αPPARsROS

Identifiers

PMID40283130
PMCPMC12028459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.