Evidence map›Paper›PMID 40282955›Full record

ReviewMedicina (Kaunas, Lithuania)2025

New Frontiers in Nutritional and Therapeutic Interventions for Obesity Phenotypes.

Angelo Maria Patti, Rosaria Vincenza Giglio, Marcello Ciaccio, Anca Pantea Stoian, Teodor Salmen, Ioana-Cristina Bica, Imran Rangraze, Mohamed El Tanani, Manfredi Rizzo, Ali Abbas Rizvi

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Observational
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angelo Maria PattiInternal Medicine Unit, "Vittorio Emanuele II" Hospital, 91022 Castelvetrano, Italy.
Rosaria Vincenza GiglioDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, 90133 Palermo, Italy.
Marcello CiaccioDepartment of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, 90133 Palermo, Italy.ORCID 0000-0001-6120-9041
Anca Pantea StoianDepartment of Diabetes, Nutrition and Metabolic Diseases, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-0555-526X
Teodor SalmenDoctoral School, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-4548-7441
Ioana-Cristina BicaDoctoral School, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Imran RangrazeInternal Medicine Department, College of Medical Sciences, Ras Al Khaimah Medical & Health Sciences University (RAKMHSU), Ras Al Khaimah 11172, United Arab Emirates.
Mohamed El TananiInternal Medicine Department, College of Medical Sciences, Ras Al Khaimah Medical & Health Sciences University (RAKMHSU), Ras Al Khaimah 11172, United Arab Emirates.
Manfredi RizzoInternal Medicine Department, College of Medical Sciences, Ras Al Khaimah Medical & Health Sciences University (RAKMHSU), Ras Al Khaimah 11172, United Arab Emirates.ORCID 0000-0002-9549-8504
Ali Abbas RizviDepartment of Medicine, Division of Endocrinology, Orlando VA Medical Center and University of Central Florida College of Medicine, Orlando, FL 32827, USA.ORCID 0000-0002-3714-0790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heterogeneity among patients with obesity is particularly evident in the weight loss response to interventions such as diets, drugs, devices and surgery. Obesity can be "catalogued" into four phenotypes: hungry brain (abnormal satiety for alteration of gut-brain axis), emotional hunger (hedonic eating), hungry gut (abnormal duration of satiety for faster gastric emptying) and slow burning (slowing of the metabolic rate). Phenotypes are grafted onto this complexity, the recognition of which allows for personalized medicine and increasingly targeted therapies. Although there are no standardized treatment protocols, we present management options consisting of lifestyle modifications and pharmacologic therapies. Nutritional advice and encouragement of adequate physical activity lead to increased self-efficacy and promote a sense of well-being when coupled with psychological approaches involving mindful eating. In summary, obesity has a complex pathophysiology best addressed through a therapeutic process suited to the phenotype encountered and in synergy with multifactorial interventions.

Indexed as

ObesityHumansPhenotypeWeight Lossdrugsgut–brain axisobesity phenotypespersonalized medicinetherapies

Identifiers

PMID40282955
PMCPMC12029119

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.