Evidence map›Paper›PMID 40282723›Full record

ArticleFoods (Basel, Switzerland)2025

Preparation and Characterization of Vitamin D3-Based Binary Amorphous Systems.

Xiaoshuo Zhao, Xuemei Wang, Qiuyang Wu, Yiyang Cao, Xuening Song, Yingting Luo, Zisheng Luo, Jingwen Liu, Hao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoshuo ZhaoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Xuemei WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Qiuyang WuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Yiyang CaoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Xuening SongCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Yingting LuoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Zisheng LuoCollege of Biosystem Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.
Jingwen LiuDepartment of Pharmacy, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China.
Hao ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.ORCID 0000-0002-7758-5161

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D3 (VD3) is an essential nutrient for human health that plays a key role in bone health and immune regulation. However, VD3 deficiency has become a common issue worldwide due to insufficient daily intake and inadequate conversion from sunlight exposure. The relatively poor aqueous solubility of VD3 is one of the major challenges in the development of oral supplements and functional foods, since it usually results in low oral absorption. In this study, a total of 11 potential binary systems were prepared by solvent evaporation. The binary amorphous system of VD3 and L-arginine (ARG) has been found to be the most promising binary system, since the VD3-ARG system can significantly improve the solubility of VD3, with an 80-fold enhancement relative to neat crystalline VD3. The amorphization of the VD3-ARG binary system was confirmed and the morphology was observed. Molecular interactions between VD3 and ARG were mainly attributed to hydrogen bonding, and three specific bonding sites were revealed. Furthermore, superior dissolution behavior was observed in the VD3-ARG binary amorphous system compared to the neat VD3. A significantly higher saturation level was achieved and the saturation maintained for the desired period. Overall, this study developed a promising formulation strategy to enhance the solubility of VD3, which can be further applied in functional foods for VD3 supplements.

Indexed as

amorphousL-argininesolubilityvitamin D3

Identifiers

PMID40282723
PMCPMC12026574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.