Evidence map›Paper›PMID 40282528›Full record

ReviewCancers2025

Molecular-Targeted Fluorescence Lymph Node Imaging Could Play a Clinical Role in the Surgical Setting: A Systematic Review.

Bo E Zweedijk, Sebastiaan W R Dalmeijer, Labrinus van Manen, Hidde A Galema, Lorraine J Lauwerends, Hamed Abbasi, Bernd Kremer, Cornelis Verhoef, Dominic J Robinson, Sjors A Koppes and 4 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bo E ZweedijkDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0009-0000-9256-6770
Sebastiaan W R DalmeijerDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-1444-5484
Labrinus van ManenDepartment of Otorhinolaryngology, Groene Hart Hospital, Bleulandweg 10, 2803 HG Gouda, The Netherlands.
Hidde A GalemaDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-7777-0754
Lorraine J LauwerendsDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-9704-7806
Hamed AbbasiDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-0655-7187
Bernd KremerDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Cornelis VerhoefDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-9980-8613
Dominic J RobinsonDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Sjors A KoppesDepartment of Pathology, Erasmus Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Alexander L VahrmeijerDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Joost R van der VorstDepartment of Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-0669-4272
Denise E HillingDepartment of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Stijn KeereweerDepartment of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, University Hospital Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-4665-6868

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lymphatic system plays a crucial role in the spread of solid tumors and is often the first site of metastasis, as cancer cells typically invade nearby lymph nodes (LN) before potentially spreading to other LNs through the lymphatic system and distant organs through the bloodstream [...].

Indexed as

fluorescence-guided surgeryfluorescence imagingimage-guided surgeryintraoperative imaginglymph node metastasesmolecular imagingoptical imagingtumor-specific

Identifiers

PMID40282528
PMCPMC12025374

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.