Evidence map›Paper›PMID 40282472›Full record

ArticleCancers2025

Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue Sarcoma: Updated Review and Clinical Recommendations.

Raquel Lopes-Brás, Paula Muñoz, Eduardo Netto, Juan Ángel Fernández, Mario Serradilla-Martín, Pablo Lozano, Miguel Esperança-Martins, Gerardo Blanco-Fernández, José Antonio González-López, Francisco Cristóbal Muñoz-Casares and 3 more

Abstract readConsensus Statement
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Role of cytoreductive surgery in the management of peritoneal metastases for gastrointestinal stromal tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Raquel Lopes-BrásDepartment of Medical Oncology, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, 1649-028 Lisbon, Portugal.ORCID 0000-0002-8976-3199
Paula MuñozDepartment of General Surgery and Surgical Oncology, Hospital Quironsalud Torrevieja, 03184 Torrevieja, Spain.ORCID 0000-0002-6334-3014
Eduardo NettoDepartment of Radiation Oncology, Instituto Português de Oncologia de Lisboa, 1099-023 Lisbon, Portugal.
Juan Ángel FernándezDepartment of General Surgery, Hospital Universitario Los Arcos del Mar Menor, 30739 Murcia, Spain.ORCID 0000-0003-3080-8521
Mario Serradilla-MartínDepartment of Surgery, Hospital Universitario Virgen de Las Nieves, Instituto de Investigación Biosanitaria Ibs.GRANADA, School of Medicine, University of Granada, 18014 Granada, Spain.ORCID 0000-0002-2466-0711
Pablo LozanoDepartment of Surgical Oncology, Hospital General Universitario Gregorio Marañon, Universidad Complutense de Madrid, 28009 Madrid, Spain.ORCID 0000-0002-5413-8449
Miguel Esperança-MartinsDepartment of Medical Oncology, Hospital Santa Maria, Centro Hospitalar Universitário Lisboa Norte, 1649-028 Lisbon, Portugal.ORCID 0000-0002-6858-7341
Gerardo Blanco-FernándezDepartment of Hepato-pancreatic-biliary Surgery and Liver Transplantation, Hospital Universitario de Badajoz, Universidad de Extremadura, 06080 Badajoz, Spain.ORCID 0000-0003-4845-5306
José Antonio González-LópezDepartment of Surgery, Hospital Universitario Santa Creu i Sant Pau, 08025 Barcelona, Spain.ORCID 0000-0001-8630-1952
Francisco Cristóbal Muñoz-CasaresPeritoneal Carcinomatosis and Retroperitoneal Sarcomas Unit, San Juan de Dios Hospital, 14012 Córdoba, Spain.ORCID 0000-0003-4637-4692
Isabel FernandesEpiDoC Unit, CHRC, Nova Medical School, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.ORCID 0000-0003-4032-7713
José Manuel Asencio-PascualHepatobiliary Surgery and Liver Transplant Unit, Gregorio Marañón University Hospital, 28007 Madrid, Spain.
Hugo VasquesDepartment of Surgery, Instituto Português de Oncologia de Lisboa, 1099-023 Lisbon, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver metastases from soft tissue sarcoma (STS) (excluding gastrointestinal stromal tumors) are rare and more commonly arise from retroperitoneal and intra-abdominal primary sites. Chemotherapy remains the mainstay of treatment for disseminated disease, but its effectiveness is limited and patients typically have a dismal prognosis with short survival. However, when metastases are confined to the liver (without pulmonary involvement), some patients may benefit from local techniques, either surgical or nonsurgical, that can provide long periods of disease-free survival. Due to the rarity of STS, especially with liver metastases, and the heterogeneity of histologies and biological behavior, there is a lack of standardized treatment guidelines and universally accepted criteria for this specific setting. To fill this gap, a multidisciplinary working group of experts in sarcoma and liver surgery reviewed the literature and available evidence and developed a set of clinical recommendations to be voted and discussed in the I Ibero-American Consensus on the Management of Metastatic Sarcoma, held at the III Spanish-Portuguese Update Meeting on the Treatment of Sarcomas in May 2024. Herein, the voting results of this meeting and the resulting consensus recommendations are presented, and their applicability, strengths, and limitations are discussed.

Indexed as

ablative techniquesliver metastasesliver surgeryoligometastatic diseaseretroperitoneal sarcomasoft tissue sarcoma

Identifiers

PMID40282472
PMCPMC12025635

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.