Evidence map›Paper›PMID 40282405›Full record

ArticleGenes2025

Whole-Genome Insights into the Genetic Basis of Conformation Traits in German Black Pied (DSN) Cattle.

Amelie Mandel, Monika Reißmann, Gudrun A Brockmann, Paula Korkuć

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amelie MandelAlbrecht Daniel Thaer-Institute for Agricultural and Horticultural Sciences, Animal Breeding and Molecular Genetics, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Monika ReißmannAlbrecht Daniel Thaer-Institute for Agricultural and Horticultural Sciences, Animal Breeding and Molecular Genetics, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.
Gudrun A BrockmannAlbrecht Daniel Thaer-Institute for Agricultural and Horticultural Sciences, Animal Breeding and Molecular Genetics, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.ORCID 0000-0002-4387-2947
Paula KorkućAlbrecht Daniel Thaer-Institute for Agricultural and Horticultural Sciences, Animal Breeding and Molecular Genetics, Humboldt-Universität zu Berlin, Invalidenstr. 42, 10115 Berlin, Germany.ORCID 0000-0002-3772-9562

Funding

Federal Office for Food and Agriculture 2815NA010
6 · The paper itself

Abstract

backgroundThe German Black Pied Dairy (DSN) cattle is an endangered dual-purpose breed considered an ancestor of the modern Holstein population. DSN is known for its high milk yield, favorable milk composition, and good meat quality. Maintaining a functional body structure is essential for ensuring sustained performance across multiple lactations in dual-purpose breeds like DSN. This study aims to identify candidate genes and genetic regions associated with conformation traits in DSN cattle through genome-wide association studies (GWAS).

methodsThe analysis utilized imputed whole-genome sequencing data of 1852 DSN cows with conformation data for 19 linear traits and four composite scores derived from these traits. GWAS was performed using linear mixed models.

resultsIn total, we identified 118 sequence variants distributed across 24 quantitative trait locus (QTL) regions comprising 74 positional candidate genes. Among the most significant findings were variants associated with "Rump width" on chromosome 21 and "Teat length" on chromosome 22, with

conclusionsSelective breeding for favorable alleles of the investigated conformation traits may contribute to DSN's longevity, robustness, and overall resilience. Hence, continuous focus on healthy udders, feet, and legs in herd management contributes to preserving DSN's positive traits while improving conformation.

Indexed as

Quantitative Trait LociAnimalsBreedingCattleFemaleGenome-Wide Association StudyPhenotypePolymorphism, Single NucleotideWhole Genome Sequencingconservationdual-purpose cattleendangered cattle breedgenome-wide association study (GWAS)whole-genome sequencing (WGS)

Identifiers

PMID40282405
PMCPMC12027004

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.