Evidence map›Paper›PMID 40282388›Full record

ReviewGenes2025

Genetics of Suicide.

Mostafa Khalil, Anil Kalyoncu, Alfredo Bellon

Abstract readReview
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mostafa KhalilBrown University, Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Providence, RI 02912, USA.
Anil KalyoncuPenn State Hershey Medical Center, Department of Psychiatry and Behavioral Health, Hershey, PA 17033, USA.
Alfredo BellonPenn State Hershey Medical Center, Department of Psychiatry and Behavioral Health, Hershey, PA 17033, USA.ORCID 0000-0003-2669-084X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past two decades, suicide has consistently ranked among the leading causes of death in the United States. While suicide deaths are closely associated with uicidal ideation and attempts, these are not good predictors of future suicide deaths. Establishing who is at risk of suicide remains a challenge that is mostly hampered by the lack of understanding of its pathophysiology. Nonetheless, evidence continues to accumulate suggesting that suicide is driven by a complex and dynamic interaction between environmental factors and genetics. The identification of genes that place people at risk of suicide remains elusive, but data are rapidly evolving. In this narrative review, we describe how Tryptophan hydroxylase (TPH) genes, particularly

Indexed as

SuicideTryptophan HydroxylaseBrain-Derived Neurotrophic FactorEpigenesis, GeneticGenetic Predisposition to DiseaseHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemBrain-Derived Neurotrophic FactorTPH1 protein, humanTPH2 protein, humanTryptophan HydroxylaseBDNFcortisoldepressionGABAinflammationserotoninstress

Identifiers

PMID40282388
PMCPMC12027201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.