ArticleGenes2025
The Polygenic Risk Score for Parkinson's Disease Is Associated with Becoming a Medical Doctor or Dentist.
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
BACKGROUND/
objectivesMultiple independent studies indicate an association between the occupations of medical doctors and dentists and the risk of Parkinson's disease (PD). This study tried to evaluate the associations between a polygenic risk score (PRS) for Parkinson's disease (PD) and medical career (medical doctor/dentist).
methodsThis population-based cross-sectional study used data from the UK Biobank. A total of 92,566 and 166,531 men and women aged 38-73 years, recruited between 2006 and 2010, were included in the analyses of job history and current job, respectively (separate samples). Odds risks for the jobs of medical doctors and dentists were estimated using logistic regression. A PRS of polymorphisms previously shown to predict PD best was constructed and associated with the job history of medical doctors/dentists in the first analysis and with current medical doctor/dentist jobs in the second analysis after regressing out confounding variables.
resultsA high PD PRS was associated with employment as a medical doctor or dentist for both the 92,566 individuals with job history data, with an increase of 1 standardized deviation (
conclusionsThese results suggest that PD has shared genetic routes with a propensity for higher education and becoming medical doctors/dentists.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.