Evidence map›Paper›PMID 40282191›Full record

ArticleBiology2025

Leucine-Rich Repeat Kinase 1 Signaling Targets Proteins Critical for Endosome/Lysosome Sorting and Trafficking in Osteoclasts.

Weirong Xing, Yian Chen, Anakha Udayakumar, Haibo Zhao, Subburaman Mohan

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weirong XingThe Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA.
Yian ChenThe Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA.
Anakha UdayakumarThe Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA.
Haibo ZhaoSouthern California Institute for Research and Education, Long Beach, CA 90815, USA.ORCID 0000-0003-0836-7555
Subburaman MohanThe Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA.ORCID 0000-0003-0063-986X

Funding

Molecular Mechanisms of LRRK1 Regulation of Bone HomeostasisR01AR078843 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI Weirong Xing · 2022 to 2026
$1.3M
Mechanisms of Lrrk1 Regulation of Osteoclast FunctionR21AR066831 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI XING, WEIRONG · 2014 to 2015
$334k
NIAMS NIH HHS R01 AR078843NIAMS NIH HHS R21 AR066831NIH HHS 1R01AR078843-01A1VA IK6 BX005381
6 · The paper itself

Abstract

Global knockout (KO) of the

Indexed as

cofilin 1endosome sortingknockout miceLrrk1lysosomeosteoclastosteopetrosisphosphoproteinproteomicsVPS35

Identifiers

PMID40282191
PMCPMC12024951

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.