Evidence map›Paper›PMID 40282096›Full record

ArticleBehavioral sciences (Basel, Switzerland)2025

Cortisol as a Biomarker for Stress During the Assessment and Treatment of Destructive Behavior.

Sean W Smith, Paul R Johnson, William E Sullivan, Courtney R Mauzy, Beatriz E Arroyo Antúnez, Andrew R Craig, Alexandra R Howard, Thanh Nguyen, Chelsea Hoffman, Samhitha Adavikolanu and 1 more

Abstract read
In one paragraph

Article in Behavioral sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Measurement of Hair Cortisol Throughout Gestation.Journal of clinical medicine · 2026
    Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sean W SmithBiobehavioral Health Unit, 655 Madison St., Syracuse, NY 13210, USA.ORCID 0000-0002-4219-8735
Paul R JohnsonDepartment of Clinical Laboratory Science, SUNY Upstate Medical University, 766 Irving Avenue, Syracuse, NY 13210, USA.ORCID 0000-0003-2661-9197
William E SullivanDepartment of Pediatrics, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA.ORCID 0000-0001-7790-3329
Courtney R MauzyDepartment of Pediatrics, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA.ORCID 0000-0002-9664-5879
Beatriz E Arroyo AntúnezDepartment of Pediatrics, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA.ORCID 0000-0003-4286-3915
Andrew R CraigDepartment of Pediatrics, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA.
Alexandra R HowardBiobehavioral Health Unit, 655 Madison St., Syracuse, NY 13210, USA.
Thanh NguyenBiobehavioral Health Unit, 655 Madison St., Syracuse, NY 13210, USA.
Chelsea HoffmanDepartment of Pediatrics, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA.
Samhitha AdavikolanuDepartment of Pediatrics, SUNY Upstate Medical University, 750 East Adams St., Syracuse, NY 13210, USA.
Henry S RoaneBiobehavioral Health Unit, 655 Madison St., Syracuse, NY 13210, USA.

Funding

Thomas B. Golisano N/AUpstate Medical University College of Health Professions Interprofessional Research Committee Funds for Interprofessional Inclusive Research N/A
6 · The paper itself

Abstract

Behavior-analytic treatments successfully reduce individuals' destructive behavior (e.g., self-injurious behavior, aggression, property destruction, disruption); however, there is limited research evaluating these treatments' effects on individuals' physiological stress responses, even though stress can have significant negative impacts on quality of life. Research from other fields has demonstrated that salivary cortisol concentration is a valid biomarker for stress, so researchers could potentially use this biomarker to assess the stress of individuals with limited communication repertoires who also engage in destructive behavior. The purpose of this research was to assess changes in salivary cortisol concentrations as a biomarker for stress with two participants to evaluate whether conditions that evoke destructive behavior induce stress relative to conditions that do not evoke destructive behavior. For one participant, salivary cortisol concentrations tended to increase following exposures to stimuli that evoked destructive behavior compared to conditions that did not evoke destructive behavior. The other participant had elevated salivary cortisol concentrations across all conditions. Salivary cortisol may be a useful biomarker for evaluating physiological stress as an outcome measure during research on the assessment and treatment of destructive behavior.

Indexed as

assessmentbiomarkercortisoldestructive behaviorstresstreatment

Identifiers

PMID40282096
PMCPMC12024409

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.