Evidence map›Paper›PMID 40281928›Full record

ArticleAnimals : an open access journal from MDPI2025

Genome-Wide Association Study Reveals Genetic Mechanisms Underlying Intersex and Aproctia in Large White Pigs.

Yajun Li, Jiaxin Shi, Yingshan Yang, Donglin Ruan, Jie Wu, Danyang Lin, Zihao Liao, Xinrun Hong, Fuchen Zhou, Langqing Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yajun LiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jiaxin ShiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yingshan YangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Donglin RuanState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jie WuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Danyang LinState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zihao LiaoState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Xinrun HongState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Fuchen ZhouState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0003-2926-3659
Langqing LiuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jie YangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-7031-2160
Ming YangCollege of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Enqin ZhengState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhenfang WuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Gengyuan CaiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zebin ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, State Regional Livestock and Poultry Genebank, Guangdong Genebank of Livestock and Poultry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital developmental abnormalities in piglets, such as intersex and aproctia, adversely affect survival rates, growth performance, and genetic breeding efficiency in pig populations. To elucidate their genetic basis, we performed a genome-wide association study (GWAS) on 1030 Large White pigs. We combined 50 K SNP chip data with SWIM-based genotype imputation to enhance the resolution of genetic variation detection, followed by MLM analysis. Our results identified 53 significant SNPs, with 52 associated with intersex and 1 with aproctia. Key candidate genes included MAD1L1, ID4, EFNA5, and PPP1R16B for intersex and ARNT2 for aproctia. Functional enrichment analysis highlighted pathways related to gonadal development (e.g., progesterone-mediated oocyte maturation) and embryonic morphogenesis. Collectively, the identification of these SNPs and candidate genes advances our understanding of the genetic architecture of intersex and aproctia in piglets. These findings provide actionable insights for optimizing genetic breeding strategies and improving health management in Large White pig production, with potential implications for reducing economic losses caused by congenital disorders.

Indexed as

aproctiachip datagenome-wide association studiesimputed dataintersexmixed linear models

Identifiers

PMID40281928
PMCPMC12024236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.