ArticleBioengineering (Basel, Switzerland)2025
Causal Links Between Corneal Biomechanics and Myopia: Evidence from Bidirectional Mendelian Randomization in the UK Biobank.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Effects of orthokeratology with different back optic zone diameters on corneal biomechanics and myopia control: a 1-year randomized, double-blind, self-controlled study.Eye and vision (London, England) · 2026Article
- Relationship Between Lifestyle During School Years, Ocular Biomechanics and Refractive Status in Adult Myopes.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- The role of anterior segment biomarkers in the development and progression of myopia.Taiwan journal of ophthalmologyReview
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Authors and funding
7 authors.
Funding
Abstract
backgroundMyopia is a leading cause of visual impairment worldwide, and accumulating evidence suggests that biomechanics may be closely linked to its development. Understanding this relationship may help clarify the underlying mechanisms of myopia and guide treatment strategies. The aim of the study is to investigate the causal relationship between myopia and corneal biomechanics using the UK Biobank (UKB) database.
methodsData from 11,064 eyes in the UKB, including refraction results and Ocular Response Analyzer (ORA) measurements, were analyzed. Eyes were categorized by spherical equivalent (SE) into emmetropia, mild myopia, moderate myopia, and high myopia. One-way ANOVA assessed differences in corneal biomechanical parameters across the varying myopia groups, while Quantile Regression (QR) explored the relationship between these parameters and myopia severity across the different quantiles. A Mendelian randomization (MR) analysis was employed to explore the causal relationships.
resultsSignificant differences in corneal biomechanical parameters and intraocular pressure (IOP) were observed across the myopia levels (
conclusionsThis study establishes a causal relationship where reduced corneal biomechanics contribute to myopia, while myopia itself does not directly affect biomechanics. Corneal biomechanics could serve as a biomarker for assessing high myopia risk. These findings offer new insights into high myopia's pathological mechanisms and targeted prevention.
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