ArticleBioengineering (Basel, Switzerland)2025
Randomised Clinical Trial: Effect of AH Plus and Neosealer Flo on Postoperative Pain and Healing of Periapical Lesions.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy of novel biomaterials versus traditional materials in the treatment of dental and pulpal diseases: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Short-term radiographic changes of extruded NeoSealer Flo in a simulated enlarged-apex model: influence of moisture and periapical support.Clinical oral investigations · 2026Article
- Influence of different drying protocols on bond strength of epoxy resin- and calcium silicate- based root canal sealers in nonsurgical retreatment.BMC oral health · 2026Article
- Single cone versus carrier-based obturation using a premixed bioceramic sealer in postgraduate master cohort: a 36 months retrospective evaluation.Clinical oral investigations · 2026Article
- Five-year clinical outcomes of root canal treatment using a calcium silicate-based sealer in teeth with apical periodontitis: a retrospective cohort study.Clinical oral investigations · 2026Article
- Adverse tissue reaction to a next-generation bioceramic sealer: a structured literature review and case report.Frontiers in dental medicine · 2026Review
- Hexaallylaminocyclotriphosphazene-Modified Dental Compositions for 3D Printing of Dental Crowns.Polymers · 2025Article
- Functional and Bioactive Performance of Premixed Bioceramic Sealers with Warm Obturation: A Scoping Review.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Apical periodontitis is a common inflammatory condition associated with root canal treatment (RCT) failure. The quality of the three-dimensional root canal seal is critical to the success of the treatment. Bioceramic sealants, such as Neosealer Flo, offer biological advantages such as osteoconduction, biocompatibility and sustained calcium ion release, which may improve apical healing. The aim of this study was to compare AH Plus and Neosealer Flo in terms of postoperative pain, extrusion and periapical healing. A single-blind, randomised clinical trial was conducted with 60 patients divided into AH Plus and Neosealer Flo groups. Post-operative pain was assessed using a visual analogue scale (VAS) at 24 and 48 h and at 7 days. Seal quality and periapical healing were assessed at 6 months using the AAE success criteria by clinical and radiographic evaluation. Neosealer Flo resulted in less postoperative pain at 24 h and 7 days compared to AH Plus. Extrusion did not significantly affect pain or correlate with the type of sealer used. Both materials achieved similar periapical healing rates. Neosealer Flo demonstrated advantages in pain reduction, while both sealants showed comparable efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.