Evidence map›Paper›PMID 40281701›Full record

ReviewBioengineering (Basel, Switzerland)2025

Current Research in Drug-Free Cancer Therapies.

Akshaya Andavar, Varsha Rajesh Bhagavathi, Justine Cousin, Nirvi Parekh, Zahra Sadat Razavi, Bo Tan

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Iron, inflammation, and intestinal tumors: the crucial triad in colorectal cancer progression and therapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Review
  3. Article
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  8. Lessons Learned from Liver-on-Chip Platform.Annals of biomedical engineering · 2025
    Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akshaya AndavarKarpagam Academy of Higher Education, Coimbatore 641021, India.
Varsha Rajesh BhagavathiSRM Easwari Engineering College, Chennai 600089, India.
Justine CousinÉcole Publique d'Ingénieurs de la Santé et du Numérique (EPISEN), Université Paris-Est Créteil (UPEC), 94000 Créteil, France.
Nirvi ParekhInstitute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400019, India.
Zahra Sadat RazaviPhysiology Research Center, Iran University Medical Sciences, Tehran 1416634793, Iran.
Bo TanInstitute of Biomedical Engineering Science and Technology (iBEST), Faculty of Engineering and Architectural Science, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada.ORCID 0000-0001-8141-4819

Funding

Mitacs 32231, 32341
6 · The paper itself

Abstract

Cancer treatment has historically depended on conventional methods like chemotherapy, radiation, and surgery; however, these strategies frequently present considerable limitations, including toxicity, resistance, and negative impacts on healthy tissues. In addressing these challenges, drug-free cancer therapies have developed as viable alternatives, utilizing advanced physical and biological methods to specifically target tumor cells while reducing damage to normal tissues. This review examines several drug-free cancer treatment strategies, such as high-intensity focused energy beams, nanosecond pulsed electric fields, and photothermal therapy as well as the use of inorganic nanoparticles to promote selective apoptosis. We also investigate the significance of targeting the tumor microenvironment, precision medicine, and immunotherapy in the progression of personalized cancer therapies. Although these approaches demonstrate significant promise, challenges including scalability, safety, and regulatory obstacles must be resolved for clinical application. This paper presents an overview of current research in drug-free cancer therapies, emphasizing recent advancements, underlying scientific principles, and the steps required for clinical implementation.

Indexed as

cancer treatmentdrug-free therapyimmunotherapynanoparticlesnanotechnologypersonalized medicine

Identifiers

PMID40281701
PMCPMC12024433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.