ArticleBMC nutrition2025
Enigmatic link between familial mediterranean fever and dietary components: a novel approach to personalized nutrition.
Article in BMC nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between pro-inflammatory diet and ulcerative colitis: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Does COVID-19 infection change appetite and dietary habits?Medicine · 2026Article
- AA amyloidosis in familial Mediterranean fever: a comparative study of clinical and genetic features between Algerian probands and their relatives.Rheumatology international · 2026Article
- Effect of inspiratory muscle training on fatigue, aerobic capacity, pulmonary functions, and quality of life in adolescents with familial Mediterranean fever: a randomized controlled trial.Irish journal of medical science · 2026Article
- Dilemma between knife and needle for acute abdominal pain in familial Mediterranean fever: Two case reports and literature review.World journal of clinical pediatrics · 2026Article
- Exploring the Role of Vitamin D in Familial Mediterranean Fever: Pathogenesis, Triggers, and Immune Modulation.Medical sciences (Basel, Switzerland) · 2026Review
- Nutritional Status and Nutrient Intake of Children With Feeding Disorders in Early Childhood.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Mediterranean diet adherence in pediatric familial Mediterranean fever: clinical and inflammatory correlates.Frontiers in pediatrics · 2026Article
- Association of Mediterranean diet adherence with familial Mediterranean fever severity in a Lebanese cohort.Pediatric rheumatology online journal · 2025Article
- Comprehensive phytochemical profiling of bioactive compounds fromBiochemistry and biophysics reports · 2025Article
- Arsenic and heavy metal contamination in drinking water from an industrial zone in Dhaka District, Bangladesh.PloS one · 2025Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite its prevalence, Familial Mediterranean Fever (FMF) remains poorly understood, with limited therapeutic options available to manage its debilitating symptoms. The discovery of a potential link between FMF and dietary components has sparked new hope for personalized nutritional interventions, yet the complex interplay between genetic and environmental factors underlying disease pathogenesis remains unclear.
objectivesThis study aimed to investigate the complex relationships between dietary components, nutrient profiles, and FMF symptoms, with a focus on developing personalized nutrition strategies for FMF management.
methodsThis cross-sectional study recruited 100 FMF patients and 50 healthy controls, matched for age, sex, and ethnicity. Participants completed a comprehensive food frequency questionnaire, and blood samples were analyzed for biomarkers of inflammation and nutrient profiles. Advanced statistical methods were employed to identify patterns and correlations between dietary components, nutrient profiles, and FMF symptoms.
resultsThe study revealed significant correlations between FMF symptom severity and specific dietary components, including pro-inflammatory omega-6 fatty acids, advanced glycation end-products, and lectins, as well as anti-inflammatory omega-3 fatty acids, antioxidants, and fiber. Factor analysis identified four distinct dietary patterns, which collectively explained 92.86% of the variance in FMF symptom severity. The adoption of an anti-inflammatory diet was associated with improved symptom management and quality of life.
conclusionsThis study provides novel insights into the complex relationships between dietary components, nutrient profiles, and FMF symptoms, highlighting the potential for personalized nutrition strategies to revolutionize FMF management. The identification of specific dietary components associated with FMF symptom severity has significant implications for the development of targeted dietary recommendations that address individual patients' unique requirements. Further research is necessary to fully elucidate the mechanisms underlying these relationships and to develop effective personalized nutrition strategies for FMF management. WHO CLINICAL TRIAL REGISTRY: TCTR20241022008 (Familial Mediterranean Fever - Dietary Habits and Symptom Management, Date of Registration: 17 November, 2024) ( https://www.thaiclinicaltrials.org/show/TCTR20241022008 ).
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