ArticleEvoDevo2025
Early embryonic development in the tick Ixodes scapularis suggests syncytial organization and cellularization before blastoderm formation.
Article in EvoDevo, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Insights into tick-pathogen interactions - a single cell RNA sequencing approach of transcriptional changes during ehrlichial infection.bioRxiv : the preprint server for biology · 2026Article
- Developmental system drift in the patterning of the arthropod tarsus.Proceedings. Biological sciences · 2026Article
- Real-time imaging on a microwell device allows first insights into the embryonic development of the ubiquitous and notorious scabies parasite.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Ixodes ticks are the most important vectors of arthropod-borne diseases in the United States, Canada, and Europe. Ixodes scapularis is the major vector that transmits the causative agent of Lyme disease in the eastern United States and can transmit up to six additional pathogens. In recent years, many advances have been made in building the toolkit for I. scapularis research, including genomic resources, transcriptomes, and forward and reverse genetics techniques. However, an understanding of the early embryonic development of this species is still lacking. In this study, we attempted to fill this knowledge gap and to further the efforts of functional genomics tools development. We developed a staging system consisting of 16 (0-15) stages describing unique morphologies and used wheat germ agglutinin staining and fluorescent dye injections to confirm cell membrane formation. These results provide an opportunity to identify an ideal time window for tick transgenics and deepen our understanding of the events during embryo development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.