Evidence map›Paper›PMID 40281592›Full record

ArticlePediatric rheumatology online journal2025

Influenza vaccination in patients with juvenile idiopathic arthritis under different treatments: safety and immune response.

Adam Gyori, Arnold Nagy, Gabor Ottoffy, Tamas Decsi, Diana Simon, Timea Berki, Timea Dergez, David Kuti, Bernadett Mosdosi

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric rheumatology online journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adam GyoriDepartment of Pediatrics, Medical School, University of Pecs, Pecs, Hungary. gyori.adam@pte.hu.
Arnold NagyDepartment of Pediatrics, Medical School, University of Pecs, Pecs, Hungary.
Gabor OttoffyDepartment of Pediatrics, Medical School, University of Pecs, Pecs, Hungary.
Tamas DecsiDepartment of Pediatrics, Medical School, University of Pecs, Pecs, Hungary.
Diana SimonDepartment of Immunology and Biotechnology, Medical School, University of Pecs, Pecs, Hungary.
Timea BerkiDepartment of Immunology and Biotechnology, Medical School, University of Pecs, Pecs, Hungary.
Timea DergezInstitute of Bioanalysis, Medical School, University of Pecs, Pecs, Hungary.
David KutiDepartment of Virology, National Center for Public Health and Pharmacy, Budapest, Hungary.
Bernadett MosdosiDepartment of Pediatrics, Medical School, University of Pecs, Pecs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnnual flu vaccination is recommended for children with rheumatic diseases. We investigated the cellular and humoral immune response and safety in pediatric patients that received inactivated influenza vaccines.

methodsThis is a comparative study of in 41 children with juvenile idiopathic arthritis (JIA) receiving influenza vaccination while being treated with methotrexate (MTX) or biological therapy. The influenza vaccination was administered as a single dose of trivalent influenza vaccine (TIV). Serological tests to monitor seroconversion and seroprotection were performed at baseline and at 4 as well as 12 weeks after vaccination.

resultsIn all of the 41 children with JIA and the 22 healthy children seroconversion and seroprotection were observed for Influenza A. For Influenza B, no adequate seroconversion rates were not detected in any of the groups studied. No significant differences were observed in lymphocyte subpopulations when analysing time points and groups simultaneously. There were no relapses or cases of influenza infection after the vaccination. Our findings do not suggest non-specific immune activation following vaccination based on the distribution and quantity of the lymphocyte subsets that were investigated.

conclusionThe present study demonstrates adequate seroprotection rates against influenza A in immunosuppressed children with JIA. The trivalent vaccine had good immunogenicity and was safe to use in both JIA treatment groups.

Indexed as

Arthritis, JuvenileInfluenza, HumanInfluenza VaccinesAdolescentAntirheumatic AgentsChildChild, PreschoolFemaleHumansImmunocompromised HostImmunosuppressive AgentsMaleMethotrexateVaccinationAntirheumatic AgentsImmunosuppressive AgentsInfluenza VaccinesMethotrexateFlowcytometryImmunogenicityInfluenza vaccineJuvenile idiopathic arthritis (JIA)Safety

Identifiers

PMID40281592
PMCPMC12023564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.