Evidence map›Paper›PMID 40281514›Full record

Trial reportBMC oral health2025

Evaluation of the effects of using an interdental brush dipped in 0.2% hyaluronic acid gel on clinical periodontal parameters among patients with periodontitis: a randomized controlled trial.

Özlem Saraç Atagün, Seval Ceylan Şen, Gülbahar Ustaoğlu, Erkan Özcan

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06309797 (Evaluation of the Effects of Using an Interdental Brush Dipped in 0.2% Hyaluronic Acid Gel on Clinical Periodontal Parameters Among Patients With Periodontitis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06309797 nacompletednot on this map

Evaluation of the Effects of Using an Interdental Brush Dipped in 0.2% Hyaluronic Acid Gel on Clinical Periodontal Parameters Among Patients With Periodontitis

TypeinterventionalSponsorÖzlem SARAÇ ATAGÜNRan2023 to 2024Enrolled60ConditionsPeriodontitisArmsInterdental brush+HA, Interdental brush
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Özlem Saraç AtagünDepartment of Periodontology, Gülhane Faculty of Dentistry, University of Health Sciences, Ankara, Turkey. ozlemsarac2806@hotmail.com.ORCID http://orcid.org/0000-0002-2964-8244
Seval Ceylan ŞenDepartment of Periodontology, Gülhane Faculty of Dentistry, University of Health Sciences, Ankara, Turkey.
Gülbahar UstaoğluDepartment of Periodontology, Gülhane Faculty of Dentistry, University of Health Sciences, Ankara, Turkey.
Erkan ÖzcanDepartment of Periodontology, Gülhane Faculty of Dentistry, University of Health Sciences, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe additional use of agents with antibacterial and anti-inflammatory activities, such as hyaluronic acid in treating periodontal disease, has recently become popular. This study aimed to evaluate the effects of using an interdental brush dipped in 0.2% HA gel on clinical periodontal parameters.

methodsThis randomized controlled trial was conducted among 60 patients with stages II/III grades A/B periodontitis. After full-mouth scaling root planning and oral hygiene training, the patients were divided into two groups; the test group was asked to use an interdental brush dipped in 0.2% HA, while the control group was asked to use a regular interdental brush. Clinical periodontal parameters [ gingival index (GI), plaque index (PI), papillary bleeding index (PBI), pocket depth (PD), and clinical attachment loss (CAL) ] were assessed at baseline and in the 1st and 3rd months after treatment.

resultsClinical periodontal parameters were improved in control and test groups at the 1 and 3-month compared to baseline (p < 0.05). The 1st- and 3rd-month PBIs were significantly lower in the test group (p < 0.05). There was no significant difference between the test and control groups regarding PI, PD, GI, and CAL between the follow-up times.

conclusionsAlthough the clinical efficacy of the tested methods of interdental brush use was similar, it can be concluded that the use of an interdental brush dipped in HA may contribute to the reduction of gingival bleeding in the early period. CLINICAL SIGNIFICANCE: Incorporating HA into the oral hygiene regime after periodontitis treatment using an interdental brush is a useful and practical method. NAME OF THE REGISTRY: https://clinicaltrials.gov/ TRIAL REGISTRATION NUMBER: NCT06309797. DATE OF REGISTRATION: 07/03/2024 "Retrospectively registered". URL: https://clinicaltrials.gov/study/NCT06309797.

Indexed as

Hyaluronic AcidPeriodontitisToothbrushingAdultDental Plaque IndexDental ScalingFemaleGelsHumansMaleMiddle AgedOral HygienePeriodontal Attachment LossPeriodontal IndexGelsHyaluronic AcidDental plaqueHyaluronic acidOral healthOral hygienePeriodontitis

Identifiers

PMID40281514
PMCPMC12023370

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.