ArticleBMC public health2025
Prediction of dementia risk by instrumental activities of daily living limitations and its impact on dementia onset in combination with mild cognitive impairment: a population-based longitudinal study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Network outcome analysis of cognitive function and daily functioning and risk of dementia among adults aged 50 years and older: an 8-year prospective study.European archives of psychiatry and clinical neuroscience · 2026Article
- [Progress on prognostic assessment methods for mild cognitive impairment].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- Activities of daily living and their neural correlates across the Alzheimer's disease continuum: Evidence from a Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between relative free-living sit-to-stand transition thigh angular velocities and difficulties in mobility and daily functioning.Aging clinical and experimental research · 2026Article
- Persistent functional impairment as an early indicator of cognitive decline and dementia in cognitively normal older adults.Journal of Alzheimer's disease : JAD · 2026Article
- Persistent Functional Impairment as an Early Indicator of Alzheimer Disease Pathology and Progression.Journal of the American Geriatrics Society · 2026Article
- Functional capacity in Peruvian people with Alzheimer's disease and frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Young-Onset Dementia: Clinical Findings and Factors That Delay Early Diagnosis-A Retrospective Observational Study.Biomedicines · 2025Article
- Daily Living, Depressive Symptoms, and Cognition in Older Adults With Chronic Diseases.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundInstrumental activities of daily living (IADL) limitations are important risk factors for dementia. IADL is lifestyle-based, therefore, its assessment content must be updated to reflect recent lifestyle changes. We evaluated the predictive validity of the National Center for Geriatrics and Gerontology Activities of Daily Living (NCGG-ADL), an IADL scale we previously developed, to identify dementia risk and the combined impact of mild cognitive impairment (MCI) and IADL limitations on dementia onset.
methodsThis population-based longitudinal study included 2,118 adults aged ≥ 65 years without dementia at baseline. At baseline, IADL limitations and MCI were assessed using the NCGG-ADL and a multi-domain neuropsychological test, respectively. The participants were followed up for new-onset dementia monthly for 5 years.
resultsAmong all participants, 247 (11.7%) had IADL limitations at baseline, and 151 (7.1%) developed dementia during follow-up. Compared to participants without IADL limitations (NCGG-ADL 13 points), those with IADL limitations (NCGG-ADL ≤ 12 points) showed a significantly higher dementia onset risk (HR: 1.55 [95% CI: 1.04-2.31]). Regarding the combined impact of MCI and IADL limitations on dementia, the HRs (95% CIs) (reference: unimpaired cognition without IADL limitations) of unimpaired cognition with IADL limitations, MCI without IADL limitations, and MCI with IADL limitations were 1.53 (0.90-2.61), 1.87 (1.28-2.74), and 2.88 (1.65-5.03), respectively.
conclusionsThis study validated the NCGG-ADL as an effective screening tool for assessing dementia risk among community-dwelling older adults. Furthermore, concomitant MCI and IADL limitations was associated with a higher risk of dementia onset more than either condition alone. Therefore, this coexisting condition should be carefully monitored to prevent dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.