ArticleBMC infectious diseases2025
Antibiotic susceptibility patterns of bacterial uropathogens at a private tertiary hospital in Uganda: a retrospective study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence of nitrofurantoin-resistant uropathogenic Escherichia coli (UPEC) in humans: a systematic review and meta-analysis.The Journal of antimicrobial chemotherapy · 2025Pooled it
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary tract infections are disproportionately prevalent in low- and middle-income countries, where a significant portion of the population relies on over the counter and self-prescriptions to manage symptoms. This practice has contributed to a concerning shift in antimicrobial resistance trends, among the most recommended treatments.
methodsA cross-sectional retrospective study was conducted at Mengo Hospital's medical laboratory, utilizing data from the hospital management system between January 2019 and July 2023. A total of 1,091 urine samples were collected and cultured on Cysteine Lactose Electrolyte Deficient agar. Of the samples analyzed, 476 showed significant bacteria growth (> 10
resultsAmong the 476 records with bacterial growth, 74.8% were females. The highest incidence of infection occurred in individuals aged 50 years and above (31.7%). The most isolated bacterial organisms were Gram-negative Escherichia coli (39.5%) and Gram-positive Staphylococcus aureus (25.6%). E.coli was most isolated among females (78.2%, p < 0.0001). Imipenem (83.9%), amikacin (72%), and nitrofurantoin (65.5%) were the antimicrobial agents to which isolated bacteria exhibited the highest sensitivity. Conversely, bacteria showed highest resistance to ciprofloxacin and ofloxacin of 65.5% and 64.5%, respectively.
conclusionsThe increasing resistance of uropathogens to commonly prescribed and affordable antibiotics is a growing concern. Ciprofloxacin, a widely used empirical treatment, has shown a significant shift towards resistance, highlighting the need for healthcare facilities to utilize bacteriology laboratories for culture and antimicrobial susceptibility testing, and surveillance to inform standard treatment guidelines.
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