ArticleBMC ophthalmology2025
Choroidal profile in patients with inactive thyroid-associated ophthalmopathy.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The impact of graves' orbitopathy on anterior segment structures and choroidal parameters.BMC ophthalmology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid associated ophthalmopathy (TAO) is a common autoimmune condition affecting orbital tissues. In this study, we aim to explore the alterations in choroidal vasculature during inactive phases of TAO by assessing choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT) in these patients.
methodsIn this cross-sectional comparative case series, enhanced-depth imaging optical coherence tomography (EDI-OCT) images were utilized to compare SFCT and CVI between patients with inactive TAO and age- and sex-matched normal individuals. For CVI assessment, foveal scans underwent binarization using the ImageJ software, with calculations based on the ratio of c (LA) to total choroidal area (TCA). Additionally, we investigated the associations between SFCT or CVI and factors such as age, gender, clinical activity score (CAS), proptosis, duration of disease, and margin to reflex distance (MRD).
resultsThe study included 50 eyes of 37 patients with inactive TAO (mean ± standard deviation (SD) age: 47 ± 11 years) and 282 eyes of 141 healthy individuals (mean ± SD age: 61 ± 11 years). SFCT and CVI were significantly higher in the TAO group compared to the control group (409.5 ± 152.7 μm vs. 249.3 ± 71.2 μm and 0.684 ± 0.037 vs. 0.629 ± 0.038, p < 0.001 for both). There was a significant negative association between age and SFCT in both univariate and multivariate analysis (r = -0.392, p = 0.003 and β = -0.04, p < 0.001, respectively). In multivariate analysis, we also noted a significant negative association between age and CVI (β = -0.09, p < 0.001). Apart from the correlation between MRD2 and SFCT (r = 0.297, p = 0.038 in univariate analysis and β = 38.15, p = 0.028 in multivariate analysis), no significant associations were observed between CVI or SFCT and clinical parameters in the TAO group (p > 0.05).
conclusionsSFCT and CVI were significantly higher in the inactive TAO group compared to healthy controls. Although SFCT was significantly affected by age, no relationship was observed between CVI and physiologicical or disease-related parameters in univariate analysis. These findings accentuate the complexity of choroidal remodeling in TAO and emphasize the multifactorial nature of its pathogenesis. Further investigations are warranted to elucidate the underlying mechanisms driving these observed alterations and their clinical implications in managing individuals with TAO.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.