Evidence map›Paper›PMID 40281391›Full record

ArticlePharmacology research & perspectives2025

Glutathione Decreases Parkinsonism-Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells.

Elif Güzel, Ayşe Arzu Sayın Şakul, Mustafa Nazıroğlu

Abstract read
In one paragraph

Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Psalmotoxin-1, a novel TRPM2 channel antagonist, reduces age-related macular degeneration-caused mitochondrial oxidative damage and apoptosis in human retinal pigment epithelial (ARPE-19) cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elif GüzelDepartment of Medical Pharmacology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-2737-0568
Ayşe Arzu Sayın ŞakulDepartment of Medical Pharmacology, Faculty of Medicine, Istanbul Medipol University, Istanbul, Türkiye.ORCID https://orcid.org/0000-0002-9354-0000
Mustafa NazıroğluDepartment of Biophysics, Faculty of Medicine, Suleyman Demirel University, Isparta, Türkiye.ORCID https://orcid.org/0000-0003-0887-6974

Funding

İstanbul Medipol Üniversitesi BAP-2023_22İstanbul Medipol Üniversitesi BAP-2023_23
6 · The paper itself

Abstract

Parkinson's disease (PD) is the most prevalent neurodegenerative disease. Previously, it was believed that aberrant iron metabolism, leading to ferroptosis due to glutathione (GSH) depletion, excessive Ca

Indexed as

FerroptosisGlutathioneOxidative StressParkinsonian DisordersTRPM Cation Channels1-Methyl-4-phenylpyridiniumCalciumCell Line, TumorDopaminergic NeuronsHumansMitochondriaNeuronsPiperazinesReactive Oxygen Species1-Methyl-4-phenylpyridiniumCalciumerastinGlutathionePiperazinesReactive Oxygen SpeciesTRPM2 protein, humanTRPM Cation ChannelsferroptosisglutathioneParkinson's diseaseSH‐SY5Y cell deathTRPM2 channel

Identifiers

PMID40281391
PMCPMC12031655

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.