Evidence map›Paper›PMID 40281388›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2025

Untargeted lipidomics profiling provides novel insights into pediatric patients with sepsis: an exploratory study.

Reyihangu Awuti, Jiayi Bai, Ye Cheng, Weili Yang, Zimei Cheng, Hetian Zhou, Guoyun Su, Kexin Wang, Yaodong Wang, Tingyan Liu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Reyihangu Awuti *Department of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Jiayi Bai *Department of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Ye Cheng *Department of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Weili YangDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Zimei ChengDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Hetian ZhouDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Guoyun SuPediatric Intensive Care Unit, Shenzhen Children's Hospital, Shenzhen, 518026, China.
Kexin WangThe Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Yaodong WangDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Tingyan LiuDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Ying LiuShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200032, China.
Weiming ChenDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China.
Hehe ChenDepartment of Critical Care Medicine, Women and Children's Hospital of Ningbo University, Ningbo, 315000, Zhejiang, China. hehebb0425@163.com.
Guoping LuDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China. lgp@fudan.edu.cn.
Caiyan ZhangDepartment of Critical Care Medicine, Department of Emergency, National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, 399 Wanyuan Rd, Minhang, Shanghai, 201102, China. zhangcy17@fudan.edu.cn.

Funding

Municipal Health System Key Supporting Discipline Project 2023ZDFC0103National Key Research and Development Program of China 2021YFC2701800National Natural Science Foundation of China 82202374Natural Science Foundation of Anhui Province 2308085MH267Natural Science Foundation of Shanghai Municipality 22ZR1408500Ningbo Medical and Health Brand Discipline PPXK2024-06Shanghai Municipal Science and Technology Major Project ZD2021CY001
6 · The paper itself

Abstract

introductionThe plasma lipidome has emerged as an important indicator for assessing host metabolic and immune status in sepsis. While previous studies have largely examined specific lipid class changes in adults sepsis, comprehensive investigations into plasma lipidomic alterations in pediatric sepsis are limited. This study aimed to characterize the plasma lipidome in pediatric sepsis using a metabolomics-based exploratory approach, providing insights into pathophysiological mechanisms and potential biomarkers.

methodsA retrospective study was conducted on pediatric patients with sepsis admitted to the pediatric intensive care unit (PICU). Untargeted lipidomics analysis using ultra-performance liquid chromatography coupled with Orbitrap mass spectrometry (UPLC-Orbitrap) was performed to compare metabolomic profiles between non-infected control patients and sepsis patients.

resultsCompared to controls, plasma lipid levels in sepsis patients decreased by 33.3%, increased by 20.2%, and remained unchanged in 46.5% of cases. A total of 1,257 differential lipids were identified in sepsis patients, with 24 lipids showing significant associations with pSOFA scores. In the recovery and deterioration subgroups, 186 differential lipids were identified, with triglyceride (TG) representing the highest proportion at 16.4%. Notably, 15 lipids with significant statistical differences were identified as differential lipid species through a comparison of those associated with pSOFA scores and those linked to sepsis prognosis. Fatty acid (FA) levels were significantly elevated in the sepsis group compared to controls, with arachidonic acid (FA(20:4)) showing the most significant increase (P < 0.001).

conclusionAlterations in plasma lipid profiles among children with sepsis reflect disease severity, systemic inflammatory responses, and sepsis prognosis. These findings underscore the prognostic potential of lipidomics and its value in understanding sepsis pathophysiology.

Indexed as

LipidomicsLipidsSepsisAdolescentBiomarkersChildChild, PreschoolFemaleHumansInfantIntensive Care Units, PediatricLipid MetabolismMaleMass SpectrometryMetabolomicsRetrospective StudiesBiomarkersLipidsFatty acidPediatric sepsisPlasma lipidomeUntargeted lipidomics

Identifiers

PMID40281388
PMCPMC12031908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.