Evidence map›Paper›PMID 40281378›Full record

SynthesisInternational urology and nephrology2025

Sedentary behavior and risk of chronic kidney disease: a systematic review and meta-analysis.

Luwen Zhang, Fangli Liu, Mengjie Li, Yujun Fan

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Luwen ZhangSchool of Nursing and Health, Henan University, Kaifeng, Henan, China.
Fangli LiuSchool of Nursing and Health, Henan University, Kaifeng, Henan, China. liufangli1229@hotmail.com.ORCID https://orcid.org/0000-0002-7249-4965
Mengjie LiSchool of Nursing and Health, Henan University, Kaifeng, Henan, China.
Yujun FanSchool of Nursing and Health, Henan University, Kaifeng, Henan, China.

Funding

Henan Provincial Department of Science and Technology Key project 242102310252Henan Provincial Department of Science and Technology Key project 252102311067Henan University Youth Cross Fund General S23060Y
6 · The paper itself

Abstract

backgroundSedentary behavior has been considered a particular risk factor for adverse health outcomes independent of exercise, becoming a widespread public health issue globally. Many studies have analyzed the effect of sedentary behavior levels on the risk of chronic kidney disease (CKD), however, previous findings have been inconsistent. This study aims to evaluate the association between sedentary behavior and the risk of CKD.

methodsEleven databases were searched for relevant cohort studies that were published between September 2024 and the databases' inception. To assess the association between sedentary behavior and risk of CKD, we calculated pooled effect sizes as relative risk (RR) with 95% CI using a random effects model. Subgroup analysis, sensitivity analysis, and publication bias analysis were performed.

resultsEight cohort studies involving 996,489 participants were identified. There was significant heterogeneity in the study (I

conclusionsProlonged sedentary behavior, particularly during leisure time, is associated with an increased risk of CKD in adults, though residual confounding should be considered.

Indexed as

Renal Insufficiency, ChronicSedentary BehaviorHumansRisk AssessmentRisk FactorsBehavioral healthChronic kidney diseaseCohort studiesMeta-analysisRenal functionSedentary behavior

Identifiers

PMID40281378

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.