Evidence map›Paper›PMID 40281352›Full record

ArticleInternational journal of clinical oncology2025

Significance of preoperative mean corpuscular volume in patients with stage II/III colorectal cancer and anemia.

Shuhei Asai, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Koji Shibata, Junichi Takamizawa, Norihiro Yuasa

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Article in International journal of clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shuhei AsaiDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan.
Hideo MiyakeDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan.
Hidemasa NagaiDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan.
Yuichiro YoshiokaDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan.
Koji ShibataDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan.
Junichi TakamizawaDepartment of Laboratory Medicine, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan.
Norihiro YuasaDepartment of Gastrointestinal Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, 3-35 Michishita-Cho, Nakamura-Ku, Nagoya, 453-8511, Japan. nyuasa0257@gmail.com.ORCID http://orcid.org/0000-0003-3118-1791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have examined the relationship between mean corpuscular volume (MCV) and prognosis of patients with colorectal cancer (CRC); however, these findings have been inconsistent. This study aimed to investigate the association between the preoperative MCV and recurrence-free survival (RFS) in patients with CRC.

methodsWe analyzed 1876 patients with stage II/III CRC who underwent R0 resection. The relationships between clinicopathological factors and RFS were investigated using univariate and multivariate analyses. The prognostic significance of the MCV was examined in various clinicopathological contexts. Anemia was defined as Hb < 13 g/dL in men and Hb < 12 g/dL in women.

resultsThe mean patient age was 69 ± 11 years. The 5-year RFS rate was 73.3%. Multivariate analysis showed that tumor location, histological grade, stage, serum carcinoembryonic antigen level, carbohydrate antigen 19-9, neutrophil/lymphocyte ratio, and MCV were significant independent risk factors for RFS. Hazard ratios for recurrence were 0.60 for MCV < 80 fL and 1.76 for MCV ≥ 100 fL, compared to MCV 80-100 fL (p < 0.033). The 5-year RFS rates were 83.4% and 58.9%, respectively. This trend was more pronounced in patients with anemia and was contradictory in those without anemia.

conclusionMCV < 80 fL and ≥ 100 fL can be an indicator of favorable and worse RFS, respectively, in patients with stage II/III CRC and anemia.

Indexed as

AnemiaColorectal NeoplasmsErythrocyte IndicesAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPreoperative PeriodPrognosisRisk FactorsAnemiaColorectal cancerMean corpuscular volumePrognosisRelapse-free survival

Identifiers

PMID40281352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.