ArticleScientific reports2025
Translational immune and metabolic markers of aging in dogs.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions.Biogerontology · 2026Article
- Multi-omic analysis of canine aging uncovers conserved aging pathways.GeroScience · 2026Article
- Nutrition Research in Aging Dogs and Cats: What We Know and What We Need to Do.Animals : an open access journal from MDPI · 2026Review
- Whole Blood Viscosity and Its Associations with Age, Hematologic Indices, and Serum Biochemical Variables in Clinically Healthy Beagle Dogs and Korean Shorthair Cats.Veterinary sciences · 2026Article
- Serum TNF-Alpha and IL-10 Predict Reduced Sensitivity to Fear- and Anxiety-Related Traits in Healthy Older Dogs: Preliminary Evidence for Immune-Personality Signatures in Later Life.Animals : an open access journal from MDPI · 2025Article
- Immunosenescence and Inflammaging in Dogs and Cats: A Narrative Review.Journal of veterinary internal medicineReview
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dogs serve as a promising aging model due to their genetic diversity, condensed lifespan, and shared living environment with humans. Alterations in the immune and metabolic parameters are hallmarks of aging in humans, but few studies have investigated these changes in dogs. We investigated the association of whole blood parameters with aging in a cross-sectional field study with a population of 451 companion dogs. Additionally, we measured total lymphocytes, total T-cells, CD4 T-cells, CD8 T-cells, B-cells, CBC, insulin and adiponectin in a cross-sectional study of 74 laboratory research beagles. In companion dogs, we report total lymphocytes and RBCs decrease significantly with age while platelets increase significantly. In lab beagles, total lymphocytes, T-cells, CD4 T-cells, CD8 T-cells, and B cells are significantly lower in Aged and Geriatric beagles. Furthermore, the CD4/CD8 ratio is significantly lower in Geriatric beagles. We also found that Geriatric beagles experience hyperinsulinemia, while plasma adiponectin is significantly lower in both Aged and Geriatric beagles. These results align with the age-related immune and metabolic alterations seen in humans and provide additional evidence that dogs serve as a relevant translational model of aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.