Evidence map›Paper›PMID 40281265›Full record

SynthesisJournal of thrombosis and thrombolysis2025

Comparison of safety and efficacy of ultrasound-accelerated thrombolysis vs. standard catheter-directed thrombolysis for the management of acute pulmonary embolism - a systematic review and meta-analysis.

Siddhant Passey, Hritvik Jain, Jagriti Jha, Kelin Zhong, Chia-Ling Kuo, Marissa Iverson, Haris Patail, Saurabh Joshi, Joseph Ingrassia

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siddhant PasseyDepartment of Internal Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.ORCID https://orcid.org/0000-0002-5569-1107
Hritvik JainDepartment of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Jagriti JhaDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA.
Kelin ZhongThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Storrs, CT, USA.
Chia-Ling KuoThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Storrs, CT, USA.
Marissa IversonHealth Sciences Library, University of Connecticut School of Medicine, Farmington, CT, USA.
Haris PatailDepartment of Cardiology, Westchester Medical Center, Valhalla, NY, USA.
Saurabh JoshiDepartment of Interventional Cardiology, Heart & Vascular Institute, Hartford Hospital, Hartford, CT, USA.
Joseph IngrassiaDepartment of Interventional Cardiology, Heart & Vascular Institute, Hartford Hospital, Hartford, CT, USA. joseph.ingrassia@hhchealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Standard catheter-directed thrombolysis (SCDT) and Ultrasound-assisted thrombolysis (USAT) are used in intermediate and high-risk pulmonary embolism (PE). SCDT uses low-dose thrombolytic agents, minimizing bleeding risk. USAT adds acoustic energy to improve fibrin breakdown and thrombolytic penetration. A systematic literature search spanning PubMed/Medline, Embase, CENTRAL, CINAHL, and ClinicalTrials.gov databases (from inception to 17 June 2024) was conducted to retrieve studies comparing USAT to SCDT for managing acute PE. Risk of bias was assessed using Cochrane tools for randomized and non-randomized trials. Odds ratio (OR) and mean difference (MD) were pooled using random effects models. Statistical analyses were performed in R version 4.2.2. 11 studies with 37,398 patients (8,762: USAT and 28,636: SCDT) were included. The mean reduction in right ventricular to left ventricular diameter ratio was lower for USAT (MD: -0.12; 95% CI: -0.19, -0.06) compared to SCDT. There was no statistically significant difference between USAT and SCDT for odds of in-hospital mortality, intracranial hemorrhage, bleeding requiring transfusion or for means of hospital or ICU length of stay, or reduction in pulmonary artery pressures. Safety or efficacy of USAT is not superior to SCDT in patients with acute PE. Results were limited due to variable infusion protocol across studies and heterogeneity of results among studies. Large-scale randomized controlled trials (RCTs) are needed to corroborate these findings.

Indexed as

Fibrinolytic AgentsPulmonary EmbolismThrombolytic TherapyUltrasonic TherapyAcute DiseaseHumansTreatment OutcomeFibrinolytic AgentsCatheter-directed interventionsCatheter-directed thrombolysisMeta-analysisPulmonary embolismUltrasound-assisted thrombolysis

Identifiers

PMID40281265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.