Evidence map›Paper›PMID 40281263›Full record

ArticleMikrochimica acta2025

A dual-channel lipid droplet-targeting probe for the detection of polarity and HOCl in models of NAFLD, inflammation, and cancer.

Tingting Yang, Shiyu Yin, Huina Liu, Shunyi Wang, Chengqi Wang, Yuxin Chen, Xiaoya Liu, Fangke Zhu, Jiaxuan Guo, Lajiatai and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tingting YangDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China.
Shiyu YinDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China.
Huina LiuDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China.
Shunyi WangDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China.
Chengqi WangDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China.
Yuxin ChenDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China.
Xiaoya LiuDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China.
Fangke ZhuFirst Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing , 210023, Jiangsu, People's Republic of China.
Jiaxuan GuoSir Run Run Hospital Nanjing Medical University, Nanjing , 211100, Jiangsu, People's Republic of China.
LajiataiTibetan Medicine Research Institute, University of Tibetan Medicine, Tibet, 850000, People's Republic of China.
Dongzhi SuonanmuTibetan Medicine Research Institute, University of Tibetan Medicine, Tibet, 850000, People's Republic of China.
Qingjia RenTibetan Medicine Research Institute, University of Tibetan Medicine, Tibet, 850000, People's Republic of China. renchen2100@qq.com.
Shenghua LiaoDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China. liaoshenghua@cpu.edu.cn.
Caolong LiDepartment of Chemistry, School of Science, China Pharmaceutical University, Nanjing , 211198, Jiangsu, People's Republic of China. licl@cpu.edu.cn.

Funding

China Postdoctoral Science Foundation 2023M733894Key Research and Development Program of Tibet Autonomous Region XZ202301ZY0015Gthe Fundamental Research Funds for the Central Universities 2632023GR26the Natural Science Foundation of Jiangsu Province BK20231021the Science and Technology Program of Tibet Autonomous Region XZ202301YD0018C
6 · The paper itself

Abstract

Abnormal lipid droplet accumulation and metabolism can precipitate various diseases. Understanding the dynamics of intracellular lipid droplets, particularly hypochlorite acid (HOCl) and polarity, is crucial for elucidating the onset and progression of these diseases. In this study, we synthesized a near-infrared fluorescent probe, NSSP, featuring a D-π-A structure, which facilitates the independent dual-response detection of HOCl and polarity. NSSP not only reveals the polarity and HOCl fluctuations in inflammatory cells and inflammation in live mice but also differentiates between normal and fatty liver tissues through two distinct channels. Furthermore, the probe has proven effective in identifying neoplasms within live murine models at both the cellular and systemic levels, thereby affirming its utility as an instrumental resource for the precocious detection of carcinomas. This offers a hopeful avenue for the diagnostic scrutiny of pathologies.

Indexed as

Fluorescent DyesHypochlorous AcidInflammationLipid DropletsNeoplasmsNon-alcoholic Fatty Liver DiseaseAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLOptical ImagingFluorescent DyesHypochlorous AcidFluorescenceHypochloriteLipid droplet targetingPolarityTumor imaging

Identifiers

PMID40281263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.