Evidence map›Paper›PMID 40281236›Full record

ArticleAAPS PharmSciTech2025

Integration of Synchronizing In Silico, In Vitro, and In Vivo Strategies for the Development of Antipsoriatic Apremilast-loaded Nanostructured Lipid Carrier Embedded in Hydrogel.

Nikita Patel, Aneri Desai, Bhavin Vyas, Pranav Shah, Mangrulkar Shubhada, Umekar Milind, Kamla Pathak, Mahavir Bhupal Chougule

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nikita PatelDepartment of Pharmaceutics and Pharmaceutical Technology, Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi, Surat, Gujarat, 394350, India.
Aneri DesaiDepartment of Pharmaceutics and Pharmaceutical Technology, Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi, Surat, Gujarat, 394350, India.
Bhavin VyasDepartment of Pharmaceutics and Pharmaceutical Technology, Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi, Surat, Gujarat, 394350, India.
Pranav ShahDepartment of Pharmaceutics and Pharmaceutical Technology, Maliba Pharmacy College, Uka Tarsadia University, Maliba Campus, Gopal Vidyanagar, Bardoli-Mahuva Road, Tarsadi, Surat, Gujarat, 394350, India. pranav.shah@utu.ac.in.ORCID http://orcid.org/0000-0003-1057-2566
Mangrulkar ShubhadaDepartment of Pharmacology, Priyadarshini J. L. College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Electronic Zone Building, Midc, Hingna Road, Nagpur, Maharashtra, 440016, India.
Umekar MilindDepartment of Pharmacology, Priyadarshini J. L. College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Electronic Zone Building, Midc, Hingna Road, Nagpur, Maharashtra, 440016, India.
Kamla PathakFaculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Paramedical Campus, Saifai, Etawah, Uttar Pradesh, 206130, India.
Mahavir Bhupal ChouguleIngenious Biopharma-Engineered Drugs and Biologics Delivery Laboratory (iBD2 Lab), Department of Pharmaceutical Sciences, Mercer University, Atlanta, Georgia, 30341, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the major challenges in the psoriasis therapies is the systemic side effects. This research investigation intended to design, formulate, and characterize topical Apremilast (APR) nanostructured lipid carriers (NLCs) embedded hydrogel. APR-loaded NLCs were prepared using the hot melt ultrasonication technique using glyceryl monostearate (GMS) and Capmul

Indexed as

Drug CarriersHydrogelsLipidsNanostructuresPsoriasisThalidomideAnimalsAnti-Inflammatory Agents, Non-SteroidalCell SurvivalChemistry, PharmaceuticalComputer SimulationDrug LiberationExcipientsGlyceridesHumansMiceAnti-Inflammatory Agents, Non-SteroidalapremilastDrug CarriersExcipientsGlyceridesglyceryl monostearateHydrogelsLipidsThalidomideApremilastHydrogelMolecular dockingNanostructured lipid carriersPsoriasisTopical

Identifiers

PMID40281236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.