Evidence map›Paper›PMID 40281217›Full record

ArticleNPJ digital medicine2025

Machine learning-based forecasting of daily acute ischemic stroke admissions using weather data.

Nandhini Santhanam, Hee E Kim, David Rügamer, Andreas Bender, Stefan Muthers, Chang Gyu Cho, Angelika Alonso, Kristina Szabo, Franz-Simon Centner, Holger Wenz and 6 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nandhini SanthanamDepartment of Biomedical Informatics at the Center for Preventive Medicine and Digital Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hee E KimDepartment of Biomedical Informatics at the Center for Preventive Medicine and Digital Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
David RügamerDepartment of Statistics, LMU Munich, Munich, Germany.
Andreas BenderDepartment of Statistics, LMU Munich, Munich, Germany.
Stefan MuthersResearch Centre Human Biometeorology, German Weather Service (DWD), Freiburg, Germany.
Chang Gyu ChoDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Angelika AlonsoClinic for Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Kristina SzaboClinic for Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Franz-Simon CentnerDepartment of Anesthesiology, Surgical Intensive Care Medicine and Pain Medicine, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-7455-1361
Holger WenzDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Thomas GanslandtDepartment of Biomedical Informatics at the Center for Preventive Medicine and Digital Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0001-6864-8936
Michael PlattenClinic for Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Christoph GrodenDepartment of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Michael NeumaierInstitute for Clinical Chemistry, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-0410-3931
Fabian SiegelDepartment of Biomedical Informatics at the Center for Preventive Medicine and Digital Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-9673-5030
Máté E MarosDepartment of Biomedical Informatics at the Center for Preventive Medicine and Digital Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. maros@uni-heidelberg.de.ORCID http://orcid.org/0000-0002-1589-8699

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The climate crisis underscores the need for weather-based predictive analytics in healthcare, as weather factors contribute to ~11% of the global stroke burden. Therefore, we developed machine learning models using locoregional weather data to forecast daily acute ischemic stroke (AIS) admissions. An AIS cohort of 7914 patients admitted between 2015 and 2021 at the tertiary University Medical Center Mannheim, Germany, with a 600,000-population catchment area, was geospatially matched to German Weather Service data. Poisson regression, boosted generalized additive models, support vector machines, random forest, and extreme gradient boosting (XGB) were evaluated within a time-stratified nested cross-validation framework. XGB performed best (mean absolute error: 1.21 cases/day). Maximum air pressure was the top predictor, with temperature exhibiting a bimodal link. Cold and heat stressor days (T

Identifiers

PMID40281217
PMCPMC12032073

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.