ArticleAAPS PharmSciTech2025
Carboplatin Co-loaded 5-Fluorouracil Nanoparticles Conjugated with Trastuzumab for Targeted Therapy in HER2
Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Revolutionizing Breast Cancer Treatment: Harnessing Ehrlich Ascites Carcinoma Model, Cancer Metabolism, and Nanotechnology-Enhanced Chemotherapy for Improved Patient Outcomes.Cell biochemistry and biophysics · 2026Review
- Breast Cancer Progression and Its Theranostic Management via Folate-Directed Targeting of Glycoprotein Receptor.Medical sciences (Basel, Switzerland) · 2025Review
- Development and evaluation of targeted liposomes for improved doxorubicin and quercetin delivery for MDR breast cancer.Therapeutic delivery · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer, the second-most common cause of cancer-related deaths among women, remains a significant global health challenge. This study focuses on developing trastuzumab (TmAb)-functionalized chitosan nanoparticles (CS-NPs) co-loaded with carboplatin and 5-fluorouracil (5-FU) for targeted treatment of HER2-positive breast cancer. The NPs were prepared via the ionic gelation method, optimized using Design of Experimentation (DoE), and characterized for particle size, zeta potential, PDI, and entrapment efficiency. TmAb conjugation was achieved using NHS and EDC, and further characterization included TEM, syringeability, hemolytic toxicity, in-vitro release, ex-vivo cell line study, and in-vivo anti-cancer activity using the Ehrlich ascites carcinoma (EAC) model. The in-vitro release studies indicated enhanced drug release at pH 5.5 over 32 h and showed first-order kinetics. The TmAb-conjugated NPs demonstrated specificity and targeting in the SK-BR-3 cell line and significant anti-cancer activity in the EAC model, with the highest tumor inhibition rate of 85.19% compared to 58.12% for the drug solution. These findings highlight the potential of TmAb-conjugated NPs for targeted breast cancer therapy, offering improved drug delivery and therapeutic efficacy, paving the way for future clinical applications to reduce side effects and overcome the limitations of conventional chemotherapy.
Indexed as
Identifiers
40281210What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.