ArticleScientific reports2025
Regulatory B cells attenuate sepsis-associated pancreatic injury by regulating T cell homeostasis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Neuro-immune Interactions in Metabolic Regulation: Brain and Adipose Tissue Crosstalk.Journal of obesity & metabolic syndrome · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sepsis is a common and life-threatening syndrome resulting from systemic and dysregulated immune response to severe infection, which contributes to morbidity and mortality in critically ill patients. This work aimed to evaluate the regulatory function of Breg cells in sepsis-associated pancreatic injury. We established mice model of sepsis-associated pancreatic injury by cecal ligation and puncture (CLP). Pancreatic injury was assessed by measuring the levels of amylase activity and histologic pancreatic injury scores. The proportions of Breg cells and T cell subsets were analyzed by flow cytometry, their secreted cytokines were detected by ELISA. The expressions of T-bet, RORγt and Foxp3 in spleen were determined by RT-PCR. The apoptosis of pancreatic cells was examined by LDH assay and Tunel, and the cell viability was detected by MTT assay. Compared to the sham group, a significantly lower percentage of Breg cells was observed in model mice. Anti-CD22 treatment exacerbated pancreatic injury, and significantly increased the percentages of Th1, Th17 cells along with the levels of IFN-γ, IL-17 in CLP-induced sepsis model, but did not affect the differentiation of Treg cells and expression of IL-10. Anti-CD22 administration promoted the expressions of T-bet and RORγt, but did not affect the Foxp3 expression. Adoptive transfer Breg cells remarkably alleviated pancreatic injury, and significantly decreased the percentages of Th1, Th17 cells along with the levels of IFN-γ, IL-17 and further promoted the percentage of Treg cells and expression of IL-10 in CLP-induced sepsis model. Moreover, adoptive transfer Breg cells inhibited the expressions of T-bet and RORγt, and promoted Foxp3 expression in model mice. Lipopolysaccharide (LPS) promoted the apoptosis in pancreatic acinar cells, which was inhibited after culturing with Breg cells in vitro. LPS remarkably upregulated the differentiation of Th1 and Th17 cells, and downregulated the differentiation of Treg cells, which could be significantly reversed by Breg cells in vitro. In conclusion, Breg cells may exhibit the protective effects by modulating T cell responses along with the cytokines in sepsis-associated pancreatic injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.