ArticleCommunications chemistry2025
Photo-thermoresponsive polypyrrole-crosslinked single-chain nanoparticles for photothermal therapy.
Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Review
- A hemoglobin-based nanozyme with ruthenium-induced nanomotor ability exhibiting photothermal and chemodynamic responses.Mikrochimica acta · 2026Article
- A decoupled and scalable solar evaporator integrating boron-enhanced polypyrrole photothermal fabric for efficient water purification.RSC advances · 2026Article
- The Core-Shell Conformational Space of Compartmentalized Single-Chain Nanoparticles by Paramagnetic and Hyperpolarized NMR Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrated tissue and serum proteomics on magnet-guided photothermal therapy using Au/Fe/Au trilayer nanodiscs.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Irradiating a chromophore allows cancer diagnostics by photoacoustic (PA) imaging, but also causes transformation of light into thermal energy and so enables therapy by photothermal effects. Useful chromophores for photothermal therapy (PTT), such as nanoconfined oligomers and polymers, should not only display an excellent light-to-heat efficiency, but in addition must display biocompatibility and good water-solubility. We in this study have designed water-dispersible, nanocaged polypyrroles (PPy), embedded into single-chain nanoparticles (SCNP, sized 6.8 - 8.9 nm) displaying thermoresponsivity, so reaching largely increased PTT-effects. Such encaged PPy-SCNPs allow an efficient photothermal heat conversion reaching temperatures up to 85°C. In a parallelized 96-well-plate-design the PPy-SCNPs can effect an almost complete death of illuminated (cancer) cells at already low concentrations (0.001 mg/mL) with low radiant fluxes. The thermoresponsivity of the SCNPs, surrounding the PPy-chains, then responds to the photothermal heat, so creating a unique self-amplifying effect for photothermal therapy and photoacoustic imaging.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.