ArticleScientific reports2025
Neural correlates of altered reward-driven attention in chronic pain and opioid use.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Contextual Modulation of Fronto-Central, Parietal, and Global Peak Alpha Frequency.European journal of pain (London, England) · 2026Article
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3 authors.
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Abstract
While attentional processing of reward may be altered in chronic pain, the neural circuits underlying these alterations, and impact from opioid use have remained unclear. To investigate the neural representation of attentional processing in chronic pain, we collected brain fMRI data from patients (fibromyalgia; taking vs. not taking opioids) vs. pain-free controls during performance of a reward task. We selected the inferior frontal gyrus (IFG) and lateral occipital cortex (LOC) as attention-relevant regions of interest. While IFG and LOC responses were not significantly different across groups, we observed decreased IFG response during reward anticipation in patients (uncorrected, p = 0.05). When evaluating LOC-IFG functional connectivity, vs. controls, we observed significantly reduced LOC-IFG connectivity in patients (p-FDR corrected = 0.026), driven by reduced connectivity in non-opioid patients. Further in non-opioid patients, we observed that the relationship between LOC-IFG connectivity and task performance was moderated by pain duration (post-hoc moderation analysis, p = 0.031), indicating cumulative influences of pain duration on attentional processing behavior/circuits. As suggested by our results, attentional processing of reward is altered in fibromyalgia within LOC-IFG brain circuits, possibly to a lesser degree in patients who take opioids, and with potential cumulative effects of longer pain duration.
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